Newton’s method is a basic tool in numerical analysis and numerous applications, including operations research and data mining. We survey the history of the method, its main ideas, convergence results, modifications, its global behavior. We focus on applications of the method for various classes of optimization problems, such as unconstrained minimization, equality constrained problems, convex ...

ANTIRETROVIRAL therapy offers highly effective and successful treatment for patients infected with HIV. The combination of these medications has consistently demonstrated durability over the past decade. However, the role of the patient in this success is vital. Patient adherence to the prescribed antiretroviral combination is known to improve viral suppression, slow progression to AIDS, and is...

The semantic web has evolved over the current web and aims to provide a web that allows for easy retrieval and accessing of information by both man and machine. It provides for a wide variety of technology stacks , language standards and software components which help both man and machine to access data easily. Intelligent information retrieval and the credibility of data is managed in semantic...

Posaconazole (PCZ) is a relatively new addition to the azole antifungals. It has fungicidal activities against Aspergillus fumigatus, Blastomyces dermatitidis, selected Candida species, Crytopcoccus neoformans, and Trichosporon. PCZ also has fungistatic activities against Candida, Coccidioides, selected Fusarium spp., Histoplasma, Scedosporium and Zygomycetes. In addition, combining the drug wi...

companion volumes could be prepared for other countries. Some of the sources available for France may not exist elsewhere, but it would be worth exploring the possibilities. For example, an analysis is included of 85 letters written by patients to a doctor over the period 1780 to 1830 (p. 19). An indication is given of the tone of the letters, of which parts of the body they mention, and of the...

Over a two-year period, 265 Norwegian orthopaedic surgeons working at 71 institutions performed 63,484 operations under a tourniquet. Their replies to a questionnaire revealed that they mostly followed modern guidelines in their use of the tourniquet. Most felt that the tourniquet could be left on for two hours, and that it could be re-applied after 15 minutes. A total of 26 complications (one ...

Clopidogrel and Its Use in Stroke Patients To the Editor: Substantial clinical data support the use of antiplatelet therapy in reducing the incidence of secondary atherothrombotic events in individuals who have experienced a transient ischemic attack (TIA) or stroke.1 The consensus based on recent trials is that antiplatelet therapy can reduce the incidence of subsequent ischemic events in thos...

Clobazam (CLB) is an older anti-epileptic drug, with a slightly different chemical structure from that of the classic benzodiazepines currently used in the treatment of epilepsy, which confers less sedative properties in terms of negative adverse effects. It is also thought to be better tolerated than other anti-epileptic drugs, whilst maintaining a very similar level of efficacy. It has been t...