Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by stellate cells in the liver, becomes a remarkable economic burden global health care system.Low therapeutic efficacy undesirable systemic effect conventional therapies limit their clinical applications to targethepatic cells.

Acipenser stellatus (stellate sturgeon) that has been intensively captured for decades represents a sturgeon species of great importance for the scientific community and fishermen. Besides overfishing and poaching, their reproduction sites have been destroyed and their natural habitats were affected by pollution. In consequence, wild populations of stellate sturgeon have decreased dramatically ...

Hepatic fibrosis reflects hepatotoxin-mediated activation of hepatic stellate cells, resulting in their proliferation and transformation to myofibroblasts that secrete collagen. This activation is suppressed by estrogen, an effect which explains the decreased risk for hepatic fibrosis enjoyed by premenopausal women and by postmenopausal women receiving hormone replacement therapy. Since stellat...

BACKGROUND Human hepatic stellate cells have been shown to be resistant to apoptotic stimuli. This is likely dependent on the activation of anti-apoptotic pathways upon transition of these cells to myofibroblast-like cells. In particular, previous studies have demonstrated an increased expression of the anti-apoptotic protein Bcl-2 and a decreased expression of the pro-apoptotic protein Bax dur...

Drug Delivery In article number 2212206, Ying Zhao, Xiaolong Qi, Guangjun Nie, and co-workers propose a liver sinusoid capillarization hepatic stellate cells activation combined regulation strategy for fibrosis treatment. Liver fenestrae restoration enhances the transport efficiency of nanomedicine through wall, which represents promising approach

Sudden death in a 66-year-old woman with squamous cell carcinoma of the oral cavity and exclusive metastatic involvement of the right stellate ganglion and right nerve vagus is reported. The patient also suffered from paroxysmal atrial fibrillation treated with quinidine. An autopsy showed exclusive metastases to the right stellate ganglion and vagus nerve, along with decreased nerve fibre dens...

Cytoglobin (CYGB), a new member of the globin family, was discovered in 2001 as a protein associated with stellate cell activation (stellate cell activation-associated protein [STAP]). Knowledge of CYGB, including its crystal, gene, and protein structures as well as its physiological and pathological importance, has increased progressively. We investigated the roles of oxygen (O2)-binding CYGB ...

We report the organization and transcription of diverged tandemly repeated Y-linked Su(Ste) genes that are considered as suppressors of testis-expressed X-linked-repeated Stellate genes that encode a protein sharing extensive homology with beta-subunit of casein kinase 2. Clustering of restriction variants is confirmed. Size variants of Su(Ste) repeats appeared to be nonhomogeneously distribute...

R esults 144 {a) Qualitative study of the motor cortex 144 (i) Pyramidal cells 144 (ii) Betz cells 144 (iii) Large stellate cells 145 (iv) Small stellate cells 146 (v) Martinotti cells 147 {b) Qualitative study of area Zb of somatic sensory cortex 148 (i c) Quantitative study of motor cortex and area of somatic sensory cortex 148 (i) Pre-classification analysis 149 (ii) Results classified by ce...