This paper is the first piece of a jigsaw puzzle in an effort to study the conditions that enable Swedish principals and preschool leaders to do a good job, create an identity and safeguard health. The present study is the first step to approach the overarching aim of understanding how principals’ and preschool leaders’ assignments are interpreted and construed and of who or what enables or pre...

End-of-life care studies on the nature of personhood are bourgeoning; however, the practices utilized for achieving personhood in end-of-life care, particularly in a cultural context in which interdependent being and collectivism prevail, remain underexplored. This study seeks to examine and conceptualize good practices for achieving the personhood of the dying elderly in residential care homes...

A general question in biochemistry is the interplay between the chemical properties of cofactors and the surrounding protein matrix. Here, the functions of NADP+ and FAD are explored by investigation of a representative monooxygenase reconstituted with chemically-modified cofactor analogues. Like pieces of a jigsaw puzzle, the enzyme active site juxtaposes the flavin and nicotinamide rings, har...

Jigsaw percolation is a model for the process of solving puzzles within a social network, which was recently proposed by Brummitt, Chatterjee, Dey and Sivakoff. In the model there are two graphs on a single vertex set (the ‘people’ graph and the ‘puzzle’ graph), and vertices merge to form components if they are joined by an edge of each graph. These components then merge to form larger componen...

Astrophysical masers are one of the most readily detected signposts of high-mass star formation. Their presence indicates special conditions, probably indicative of a specific evolutionary phase. Masers also represent the ultimate high-resolution probe of star formation with the potential to reveal information on the kinematics and physical conditions within the region at milli-arcsecond resolu...

One challenge in supramolecular chemistry is the design of versatile, self-assembling building blocks to attain total control of arrangement of matter at a molecular level. We have achieved reliable prediction and design of the three-dimensional structure of artificial RNA building blocks to generate molecular jigsaw puzzle units called tectosquares. They can be programmed with control over the...

Jigsaw percolation is a model for the process of solving puzzles within a social network, which was recently proposed by Brummitt, Chatterjee, Dey and Sivakoff. In the model there are two graphs on a single vertex set (the ‘people’ graph and the ‘puzzle’ graph), and vertices merge to form components if they are joined by an edge of each graph. These components then merge to form larger componen...

Human sex determination is a fascinating topic, particularly at the level of molecular genetics, as it represents an excellent paradigm for mammalian organ development. Recent progress has seen the addition of several new pieces to this developmental jigsaw puzzle. In mammals, the Y chromosome is male determining, and encodes a gene referred to as TDF (testis-determining factor), which induces ...

Computational modeling has become an increasingly useful tool for studying complex neuronal circuits such as the dentate gyrus. In order to effectively apply computational techniques and theories to answer pressing biological questions, however, it is necessary to develop detailed, data-driven models. Development of such models is a complicated process, akin to putting together a jigsaw puzzle ...

The large ribosomal subunit catalyzes peptide bond formation and binds initiation, termination, and elongation factors. We have determined the crystal structure of the large ribosomal subunit from Haloarcula marismortui at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins. The domains of its RNAs all have irregular shapes and fit together ...