Designing and constructing a technically complex yet efficient, fully integrated fill-finish facility is no small task. The timeframe can be long, the costs can be high, and the stakes with numerous stakeholders involved, can be even higher. But this case study of one biotherapeutic company’s new fill-finish facility in Hillsboro, Oregon, provides practical insights and steps for success for “j...

We analyze the intermediate buffer requirements in a tandem queue where service times of each customer are deterministically correlated between the servers and arbitrarily distributed between customers. The major issue at hand is the determination of intermediate buffer sizes assuring no blocking when the arrivals pattern is arbitrary and unpredictable. The analysis shows that the worst arrival...

Background. The Emergency Department (ED) is a daunting environment for the medical learner. Time pressures on the attending physicians mean that the learning needs of the medical student may, quite appropriately, be given a lower priority than the clinical needs of the patients. We propose that a collection of brief focused computer tutorials presented at the time of the patient encounter can ...

Small and medium size enterprises (SMEs) have gained competitive advantage by using Just-in-Time, Total Quality Management, and Information Technology. Cellular Manufacturing (CM) has received less attention from SMEs. This paper reports the findings of a case study of the application of Group Technology in an SME. A framework for the design and implementation of Cellular Manufacturing Systems ...

Nonlinear modeling routines are often applied in an effort to extract underlying determinism from time series data. The best of these methods perform well for short noisy time series when there is determinism in the underlying system. We show that nonlinear modeling does not distinguish between a static nonlinear transformation of linearly filtered noise and dynamic nonlinearity. To relieve thi...

As knowledge becomes a crucial asset to organization’s survival, an efficient knowledge management policy should be set up and should result into an organizational memory. Similarly, an effective eLearning program must be implemented in the organization and exploit the organizational memory to manage competence evolution. In this paper, we introduce a framework to manage organizational knowledg...

Supply chains can be disrupted at both local and global levels. Just-In-Time (JIT) companies should be particularly interested in managing supply chain failure risk as they often have very little inventory to buffer themselves when their upstream supply chain fails. We develop previous research further and present a strategic framework to manage supply chain failure in JIT supply chains. We ide...

The International Manufacturing Strategy Survey (IMSS) have collected data in 1992, 1996, 2000, and 2006. The paper does longitudinell studies on these data focussing on data relevant for Lean Management. We see that there has been an adoption of the Just in Time and Lean issues, but that there is still a way to go.

Introduction According to The National Education Association Research Division (1994), student acquisition of higher order thinking skills is of national critical concern. Increasingly, educational leaders are recognizing that the learning process is of critical importance and understanding the way individuals learn is the key to improving the educational system. There is substantial research w...