نتایج جستجو برای: juvenile dermatomyositis
تعداد نتایج: 48304 فیلتر نتایج به سال:
Purpose Performing quality clinical and translational research in juvenile dermatomyositis (JDM) is difficult due to the rarity of the disease. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) initiated a multicenter observational cohort study to create a foundational clinical database for the major rheumatic diseases of childhood, including JDM. Initial data from the JDM coho...
We describe aggressive immunosuppressive treatment of an adolescent with Susac's syndrome (SS), a disease of the microvasculature in the brain, retina, and inner ear. Because the immunopathogenesis of SS appears to have much in common with that of juvenile dermatomyositis (JDM), the patient was treated with an approach that has been effective for severe JDM. The patient's outcome provides evide...
Introduction Juvenile Dermatomyositis (JDM) is a rare serious disease (affecting 2-3 million children/year) presenting with rash and proximal muscle weakness. Serious complications can include calcinosis, GI ulceration, interstitial lung disease (ILD) and even death. It is becoming clear that JDM is a heterogeneous condition. Dividing JDM into sub-phenotypes would allow better prediction of dis...
ss Open Acce Poster presentation Differences in therapeutic approach to juvenile dermatomyositis between Europe and Latin America L Trail*1, C Ferrari1, R Cuttica2, MM Katsicas3, R Russo3, M Bandeira4, V Ferriani5, S Oliveira6, C Saad-Magalhaes7, CA Silva8, V Baca9, R BurgosVargas10, E Solis-Vallejo11, S Maillard12, C Pilkington12, R Barcellona1, M Beltramelli1, L Breda1, C Bruno1, R Cimaz1, E ...
PReS-FINAL-2184: A randomized trial in new onset juvenile dermatomyositis: prednisone versus prednisone plus cyclosporine versus prednisone plus methotrexate N Ruperto, A Pistorio, S Knupp Feitosa de Oliveira, R Cuttica, A Ravelli, M Fischbach, B Magnusson, T Avcin , K Brochard, F Corona, G Couillault, F Dressler, V Gerloni, G Sterba, F Zulian, MT Apaz, A Cespedes-Cruz, R Cimaz, C Bracaglia, R ...
Introduction Juvenile dermatomyositis (JDM) is a rare autoimmune disease with the onset in childhood involving chronic inflammation of striated muscle and skin. The disease is often leading to severe disability, prolonged decreased physical activity, which together with chronic inflammatory activity, and long-term medical treatment with glucocorticoids, contributes to the well-known risk factor...
Disease activity refers to potentially reversible aspects of a disease. Measurement of disease activity in paediatric rheumatic diseases is a critical component of patient care and clinical research. Disease activity measures are developed systematically, often involving consensus methods. To be useful, a disease activity measure must be feasible, valid, and interpretable. There are several cha...
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added ad...
Introduction MRI represents a promising tool in the assessment of disease activity in juvenile dermatomyositis (JDM). Watersensitive sequences are very sensitive to the presence of inflammation and have the potential to support diagnosis, guide muscle biopsy and monitor treatment response. So far, all MRI studies in JDM focused on pelvic and thigh musculature. Whole-body(WB)-MRI screens the ent...
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