Due to its 3 carbonic acid groups being available for bioconjugation, the TRAP chelator (1,4,7-triazacyclononane-1,4,7-tris(methylene(2-carboxyethylphosphinic acid))) is chosen for the synthesis of trimeric bioconjugates for radiolabelling. We optimized a protocol for bio-orthogonal TRAP conjugation via Cu(I)-catalyzed Huisgen-cycloaddition of terminal azides and alkynes (CuAAC), including a de...

where u — u(x, t) in some domain and v is a parameter. The occurrence of the first derivative in t and the second in x clearly indicates the equation is parabolic, similar to the heat equation, while the interesting additional feature is the occurrence of the non-linear term u du/dx. The equation thus shows a structure roughly similar to that of the Navier-Stokes equations and has actually appe...

Our problem is to evaluate a multi-valued Boolean function F through oracle calls. If F is one-to-one and the size of its domain and range is the same, then our problem can be formulated as follows: Given an oracle f(a, x) : {0, 1}n × {0, 1}n → {0, 1} and a fixed (but hidden) value a0, we wish to obtain the value of a0 by querying the oracle f(a0, x). Our goal is to minimize the number of such ...

Binary pulsars with very small radial velocity corresponds to weak orbital effect at time scale of orbital period, and thus be treated as singular ones. However such pulsars may show their binary nature at long time scale by affecting pulsar frequency derivatives. Subtracting the magnetic dipole radiation predicted frequency derivatives from the measured ones, the intensity of long term orbital...

o-Nitrobenzenesulfenamides (1) undergo acid-catalyzed methanolysis (eq 2) in acetonitrile-methanol, affording methyl o-nitrobenzenesulfenate (2). They also undergo acid-catalyzed reaction with a thiol, giving an alkyl o-nitrophenyl disulfide (eq 3). In MeCN-8.2 M MeOH the thiolysis reaction exhibits a simple fmt-order dependence on both [R'SH] and [H+] for acid concentrations in the range 0.001...

BACKGROUND Empathy plays a key role in social understanding, but its empirical measurement has proved difficult. The Empathy Quotient (EQ) is a self-report scale designed to do just that. This series of four studies examined the reliability and validity of the EQ and determined its factor structure. METHOD In Study 1, 53 people completed the EQ, Social Desirability Scale (SDS) and a non-verba...

‎Hensel [K‎. ‎Hensel‎, ‎Deutsch‎. ‎Math‎. ‎Verein‎, ‎{6} (1897), ‎83-88.] discovered the $p$-adic number as a‎ ‎number theoretical analogue of power series in complex analysis‎. ‎Fix ‎a prime number $p$‎. ‎for any nonzero rational number $x$‎, ‎there‎ ‎exists a unique integer $n_x inmathbb{Z}$ such that $x = ‎frac{a}{b}p^{n_x}$‎, ‎where $a$ and $b$ are integers not divisible by ‎$p$‎. ‎Then $|x...

conclusions although the two instruments were able to discriminate between various states, the values derived from these instruments were quite different. this distinction could have influenced the conclusions of an economic evaluation. further research is required to determine which instrument should be used in economic evaluations. results the mean and median eq-5d utility scores for the tota...

Abstract Background Health-related quality of life (HRQoL) tools are limited by the indicators included in construct and variation interpretation different researchers. Neutral Theory describes ideal that includes all relevant and, therefore, complete accuracy, or neutrality. can thereby provide framework to develop test constructs. To assess application Theory, neutrality generic (SF-36 EQ-5D)...