This article proposes a clinical guideline for the diagnosis and treatment of Kawasaki disease in the UK based on the best available evidence to date, and highlights areas of practice where evidence is anecdotal or based on retrospective data. Future research as proposed by the London Kawasaki Disease Research Group is outlined, and clinicians are invited to prospectively enroll their suspected...

Kawasaki disease is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and children. If not treated early with high-dose intravenous immunoglobulin, 1 in 5 children develop coronary artery aneurysms; this risk is reduced 5-fold if intravenous immunoglobulin is administered within 10 days of fever onset. Coronary artery aneurysms evolve dynamically over ti...

Kawasaki disease is a multisystemic vasculitis that can result in coronary artery lesions. It predominantly affects young children and is characterized by prolonged fever, diffuse mucosal inflammation, indurative oedema of the hands and feet, a polymorphous skin rash and non-suppurative lymphadenopathy. Coronary artery involvement is the most important complication of Kawasaki disease and may c...

OBJECTIVE Kawasaki disease (KD) was first reported by Tomisaku Kawasaki in 1967 in Japan. Large-scale nationwide epidemiologic surveys have been conducted continuously by the Japan Kawasaki Disease Research Committee; however, there were very few reports of KD before 1967. This study was performed to clarify when KD appeared in Japan. DESIGN We investigated the medical charts of patients who ...

Thank you very much for your email. We have completely revised our manuscript according to the suggestions made by the Reviewers. Based on the suggestion from the Reviewers, we have changed the title from “The Association between Oxidative Stress and Premature Atherosclerosis in Early Childhood Patients with Kawasaki Disease” to “The Association between Oxidative Stress and Endothelial Dysfunct...

Eighteen of a total of 22 serum specimens (81.8%) from patients with Kawasaki disease were positive for immunoglobulin G or M antibodies to human herpesvirus 6, whereas 10 of 16 age- and sex-matched healthy controls (62.5%) were seropositive. Additionally, increased geometric mean antibody titers of immunoglobulin G were shown in these patients. These results suggest that the status of human he...

We present a 35-year-old man with history of Kawasaki disease who referred with myocardial infarction, and angiography, revealing aneurysm of left main and left anterior descending coronary arteries. The patient underwent percutaneous coronary intervention and thrombectomy and was discharged after 6 d. Coronary artery sequels of Kawasaki disease should be considered as one of the underlying cau...

Medium-sized vessel vasculitis such as Kawasaki disease and polyarteritis nodosa (PAN) were discussed. Kawasaki disease is characterised by fever, strawberry tongue, cervical lymphadenopathy, erythema or oedema of palms and soles, and periungal desquamation in the subacute phase. Polyarteritis nodosa may be systemic or cutaneous. Symptoms and signs may include livedo reticularis, subcutaneous n...

We have studied by means of Monte-Carlo simulation and exact finite-size analysis, the spin-1 Blume Capel model with Glauber and Kawasaki dynamics. The Kawasaki spin exchange process flows energy into the system from an external source. Some phase diagrams of the model are presented. For some values of the parameters, the system displays a kind of self organization phenomenon within the disorde...

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