Loss of skeletal muscle mass and force occurs in situations of altered use such as denervation, immobilization, aging and microgravity. The atrophy program induced under these conditions leads to an enhanced muscle protein degradation mainly via the ubiquitinproteasome and the autophagy-lysosome systems. The aim of our work is the definition of signaling pathways involved in muscle atrophy duri...

1 2 3 The Functional Anatomy of a Perceptual Decision in the 4 Human Brain 5 6 Abbreviated Title: fMRI of a Perceptual Decision 7 8 9 Andrew S. Kayser*^, Bradley R. Buchsbaum*^, 10 Drew T. Erickson, & Mark D’Esposito 11 12 Helen Wills Neuroscience Institute 13 Department of Psychology and the Henry H. Wheeler Jr. Brain Imaging Center 14 The University of California at Berkeley 15 16 Supported b...

Wilson disease (WD) (hepatolenticular degeneration) is an autosomal recessive disorder of copper metabolism due to absence or dysfunction of a Cu P-type ATPase which is essential for the transport of copper (Cu) into the bile. The discovery of the gene cation transporting P-type ATPase involved in the copper transport in many tissues was a breakthrough in the understanding of molecular basis of...

In “The Case for Combined-Modality Therapy for LimitedStage Hodgkin’s Disease,” [1] authors Hill-Kayser, Plastaras, Tochner, and Glatstein provide a detailed, instructive, and informative discussion of the insights into the management of Hodgkin’s lymphoma that can be derived from the recently published National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)/Eastern Cooperative Onc...

TO THE EDITOR: Surely the art of science is to see the complete picture. Some respondents focus on the findings that peak blood lactate concentrations and muscle activation are reduced in hypoxia and ignore the related phenomenon that exercise in hypoxia terminates at low cardiac outputs and blood lactate concentrations. I provided a unifying explanation for these phenomena. Dr. Marcora (see Re...

Most people cannot control the exact circumstances of their dying—when they die, where they die, how they die, how people treat them when they are dying, and so forth. They cannot be sure that they will die in “a sanctuary imbued with one’s own order” (Kayser-Jones, 2001, p. 3). This is particularly true in the days ahead as limits on health care expenditures become more and more constraining. ...

grotesque was introduced to european literature by the middle of sixteenth century, though previous definitions of this terminology were available before. although this term was introduced to aesthetics at the same time with its introduction to philosophy of arts, kayser made it official and defined it as an expression of alienation and the chaotic world in the nineteenth century. grotesque, as...

Almost every time there is a genuinely important decision to be made in an organization, a group is assigned to make it -or at least to counsel and advise the individual who must make it." Hackman [23] Meeting analysis, that is the study of meeting expenses, productivity, processes, and outcomes, is relevant to GSS practice And research for several reasons. Many reviews and surveys [1, 2, 3, 15...

Why does food lose its taste when your nose is stuffed up? Why do turn signals attract the drivers’ attention more when clicking sounds are simultaneously presented? Why are we better at hearing speech in noisy environments when we see the lip movements of the speaker? These are all questions of interest for researchers in the areas of multisensory information processing. Although the scientifi...