Keloid is a common skin hyperplastic condition and paradigm of fibrotic disease. The cell interactions that underlie fibroblast hyperfunction, increased extracellular matrix stiffness, keloid formation remain elusive, which restricts the design preventative or interventional strategies with targeted purposes. Here we performed single-cell transcriptomic analysis on human unexpectedly found new ...

In extensive burns it becomes difficult for fibroblasts to migrate from the periphery of the healthy tissue and colonize the injured area. Even under such circumstances healing takes place, and this is attributed to the differentiation of circulating fibrocytes which enter the wound site. This normal cell type is identified in keloid fibroblasts: it expresses fibrocyte markers and secretes extr...

Tuen Mun Social Hygiene Clinic, 5/F Tuen Mun Eye Centre, 4 Tuen Lee Street, Tuen Mun, N.T., Hong Kong Treatment of keloids is difficult and the response to first line treatment including silicone gel sheet, compression, topical and intralesional steroid are variable. Intralesional cryosurgery (ILC) may be useful for treating some earlobe keloids not responsive to these first line treatments. IL...

Sir, Acne keloidalis, also known as folliculitis cheloidalis, acne keloid, and dermatitis papillaris capillitii, is a dermatosis that occurs most commonly on the nape of the neck of young black males. It is characterized by the presence of small, smooth, firm papules, with occasional pustules. In a minority of cases, lesions are more numerous on the vertex or crown. Over time, the papules tend ...

Sir, Keloids of the genitalia and penis are rare despite frequent surgery in this area. A careful review of the literature revealed only a few cases reported since Browne’s statement in 1949 that the skin of the penis ‘‘never forms a keloid’’ (1), and Crockett’s research attempting to classify the susceptibility of different areas of the body to keloid formation and not finding any cases affect...