نتایج جستجو برای: keloids
تعداد نتایج: 819 فیلتر نتایج به سال:
Periostin, a secreted extracellular matrix protein, is involved in the wound healing and pathological process of various human cancers. Keloid scars are fibroproliferative tumor-like lesions and develop under local hypoxia. Using suppression subtractive hybridization, in a previous study, we found that periostin is overexpressed in keloids compared with hypertrophic scars. However, little is kn...
BACKGROUND Leiomyoma have often been compared to keloids because of their fibrotic characteristic and higher rate of occurrence among African Americans as compared to other ethnic groups. To evaluate such a correlation at molecular level this study comparatively analyzed leiomyomas with keloids, surgical scars and peritoneal adhesions to identify genes that are either commonly and/or individual...
Dermal keloids are an ongoing problem for genetically predisposed patients. Minor injuries may result in abnormal scarring. Surgical excision results in a return of keloids in 50%80% of cases, and available treatment options, namely steroid injections, radiation therapy and silicone dressings, or pressure garments are not always feasible options. These methods are not hundred percent effective,...
Keloids are thick scars that grow beyond the boundaries of the original skin damage. Most lesions appear within one year of skin inflammation including burns, surgery and acne vulgaris. They are characterized by an excessive accumulation of extracellular mamx components. Keloid waning results from increased activity of fibroblasts in the dermis with imbalance between synthesis and breakdown of ...
Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression of keloids. However, the functional role of long non-coding RNA (lncRNA)-activated by TGF-β (lncRNA-ATB) in keloids has not been documented. Here we investigated the role of lncRNA-ATB in the autocrine secretion of TGF-β in keloid fibroblasts (KFs) ...
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