We investigated and evaluated the mechanisms of erectile dysfunction (ED) in a rat model of long-term ketamine administration. Adult male Sprague-Dawley rats (n = 32) were divided into four groups: namely the control group receiving intraperitoneal injection of saline, 1-month, 2-month and 3-month groups receiving daily intraperitoneal injection of ketamine (100 mg/kg/day) for 1, 2, and 3 month...

conclusions administration of intravenous ketamine at a dosage of 0.5 mg/kg immediately after anesthesia induction had a preventive effect on shivering intensity without hemodynamic alterations in children undergoing general anesthesia for tonsillectomy. results with regards to the demographic and surgical data, no significant differences between the two study groups were observed (p ≥ 0.05). s...

Medical use of ketamine has a good safety record, but recent increase of misuse is worrying. We focussed on ketamine misuse mortality figures (UK; 1993-2006), extracted both from St George‟s np-SAD database and from published mortality statistics. The 23 victims (typically males, in the 25-44 age group) self-administered themselves with a miscellany of psychoactive compounds and alcohol. Ketami...

Editor’s key points † The combined effect of ketamine and medetomidine on cognition and apoptosis was studied in mice. † No differences were seen between groups in terms of spatial memory or apoptosis. † Hyperlocomotive activity in mice receiving ketamine was attenuated by medetomidine. † Co-administration of ketamine and medetomidine may be clinically useful. Background. Ketamine is increasing...

OBJECTIVE This research was aimed to evaluate the behaviors of short- or long-term antidepressant effects of ketamine in rats exposed to chronic unpredictable stress (CUS). BACKGROUND Ketamine, a glutamate noncompetitive NMDA receptor antagonist, regulates excitatory amino acid functions, such as anxiety disorders and major depression, and plays an important role in synaptic plasticity and le...

Recent evidence suggests that cannabinoid CB(1) receptors may represent effective targets for therapeutic agents used to treat cocaine and heroin relapse. However, the role of cannabinoid CB(1) receptors in the potential treatment for other drugs of abuse is still largely unknown. The present study was conducted to determine whether cannabinoid CB(1) receptors play a similar role in relapse to ...

Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death. Additional studies are needed to determine if ketamine anesthesia results in brain cell death in the nonhuman primate and if so, to begin to define the stage of development and the duration of ketamine anesthesia necessary to produce brain...

OBJECTIVE Ketamine is a noncompetitive antagonist at the glutamatergic N-methyl-D-aspartate (NMDA) receptor that is used in human and animal medicine as an injectable anesthetic. The illegal use of ketamine as a recreational drug is rapidly growing. Very little is currently known about the consequences of repeated ketamine exposure in the human brain. Animal studies indicate that the prefrontal...

Han, Jin, Nari Kim, Hyun Joo, and Euiyong Kim. Ketamine blocks Ca2 -activated K channels in rabbit cerebral arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 285: H1347–H1355, 2003; 10.1152/ajpheart.00194. 2003.—Although ketamine and Ca2 -activated K (KCa) channels have been implicated in the contractile activity regulation of cerebral arteries, no studies have addressed the specifi...