objective: one of nonsteroidal anti-inflammatory drugs (nsaids) named as ketorolac is frequently used to relieve acute pain. current study was conducted with the aim of ketorolac efficacy measurement as a pain killer agent for controlling the primary headache in emergency departments. methods: in this study, we enrolled 50 patients with primary headache who received 60 mg ketorolac intravenousl...

BACKGROUND Acute muscle injuries are exceedingly common and non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed to reduce the associated inflammation, swelling and pain that peak 1-2 days post-injury. While prophylactic use or early administration of NSAIDs has been shown to delay muscle regeneration and contribute to loss of muscle strength after healing, little is known about t...

BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication used in the treatment of acute pain. Ketorolac trometamol (KT) is a nonnarcotic, peripherally acting nonsteroidal anti-inflammatory drug with analgesic effects comparable to certain opioids. OBJECTIVE The aim of this study was to compare the efficacy of KT and naproxen (NA) in the treatment of acut...

The use of ketorolac was studied in patients undergoing lumbar laminectomy and those receiving lumbar fusion with or without instrumentation. Laminectomy patients in the ketorolac group used significantly less narcotic analgesic than did those in the narcotic treatment group. Ketorolac patients in both surgical categories experienced better pain control than narcotic group patients did. Laminec...

PURPOSE To harvest microorganisms from the microkeratome after LASIK. To induce experimental infectious keratitis and investigate the use of routine postoperative medication. METHODS During eight consecutive days, we cultured the plate of the microkeratome after routine LASIK. Dilutions of the most frequent microorganism was prepared according to the MacFarland scale. Ten microliters were inj...

The partial phase behavior of systems composed of lecithin/isopropyl myristate (IPM)/water or ketorolac tromethamine (KT) solutions (2.5, 5, 10 and 50% w/w) at various lecithin/IPM weight ratios (km) have been investigated by the construction of phase diagrams. A commercially available soybean lecithin (namely, Epikuron 200, phosphatidylcholine purity greater than 95%) was used in this study. P...

Ketorolac tromethamine (KT) containing microemulsion-based gels (MBGs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; Epikuron 200) and oil (isopropyl myristate; IPM) and the effect of formulation variables on the release profile of the drug from MBGs through intact guinea pig skin and various artificial membr...

This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The (equimolar ratio) and tromethamine were prepared solvent co-evaporation method. solid-state properties resulting powder characterized X-ray diffraction, DSC thermal analysis, FT–IR spectroscopy, solubility, in vitro rate. crystal structure was determined single-crystal diffr...

Ketorolac, a commonly used anti-inflammatory and analgesic agent, was studied in male wistar rats. The plasma samples were analysed using chiral AGP column with UV detection. The experimental data was analysed for probable fit in the compartmental and non-compartmental models using WinNolin software. The data of (+)-R-Ketorolac and (-)-S-Ketorolac was found to fit into the compartmental as well ...