Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. Activation of brain stress systems is hypothesized to be key to the negative emotional state produced by dependence that drives drug seeking through negative reinforcement mechanisms. This review explores the ...

The endoplasmic reticulum is the central organelle within a eukaryotic cell where newly synthesized proteins are processed and properly folded. An excess of unfolded or mis-folded proteins induces ER stress signalling pathways. Usually this means a pro-survival strategy for the cell, whereas under extended stress conditions the ER stress signalling pathways have a pro-apoptotic function. CK2 pl...

BACKGROUND This study examined the predictors, mediators and moderators of parent stress in families of preschool-aged children with developmental disability. METHOD One hundred and five mothers of preschool-aged children with developmental disability completed assessment measures addressing the key variables. RESULTS Analyses demonstrated that the difficulty parents experienced in completi...

For decades, oxidative stress has been discussed as a key mechanism of endothelial dysfunction and cardiovascular disease. However, attempts to validate and exploit this hypothesis clinically by supplementing antioxidants have failed. Nevertheless, this does not disprove the oxidative stress hypothesis. As a certain degree of reactive oxygen species (ROS) formation appears to be physiological a...

malondialdehyde (mda) is widely used as a biomarker for assessing oxidative stress in biomedical fields. lipid peroxidation is a chain phenomenon resulting in the formation of various active compounds that result in cellular damage. biomonitoring of mda has been used in both in-vivo and in-vitro studies as a key biomarker for various disease patterns including hypertension, diabetes, atheroscle...

salicylic acid (sa) plays a key role in plant disease resistance and hyper-sensitive cell death but is also implicated in hardening responses to abiotic stress. the aim of this study is to examine the effects of salicylic acid on the growth, eco-physiological and biochemical characteristics in zinnia elegans plant exposed to copper stress. effects of copper (cu) on biomass, root length and shoo...

background: different postdesigns and materials are available; however, no consensus exists regarding superiority for stress distribution. the aim of this study was to evaluate the effect of design and material of post with or without ferrule on stress distribution using finite element analysis. materials and methods: a total of 12 three‑dimensional (3d) axisymmetric models of postretained cent...