objective systemic lupus erythematosus (sle), an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (cns) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (sle) patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. true n...

polyomaviruses may cause human disease, particularly in immunocompromised hosts. jcv, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (pml), which occurs mostly in immunocompromised patients. progressive multifocal leukoencephalopathy (pml) is a progressive demyelinating disorder of the central nervous sy...

A neuroinvasive respiratory coronavirus, SARS-CoV-2 causes a variety of neurological responses in patients. These include dizziness, headache, myalgias, hypogeusia, hyposmia, polyneuropathy, myositis, cerebrovascular disease, encephalitis and encephalopathy. Such susceptibility the central nervous system (CNS) to virus has spurred interest neuropsychological research COVID-19 patients convalesc...

Bacterial meningitis (BM) affects the central nervous system (CNS) and is a significant long-term sequela for 50% of survivors globally. Resource-poor areas have higher prevalence acute bacterial than resource-rich ones. The pathogenesis BM involves intricate pathways linked to survival proliferation in circulation, increased blood-brain barrier (BBB) permeability, oxidative […]

The inflammatory response is modulated through interactions among the nervous, endocrine, and immune systems. Intercommunication between immune cells and the autonomic nervous system is a growing area of interest. Spatial and temporal information about inflammatory processes is relayed to the central nervous system (CNS) where neuroimmune modulation serves to control the extent and intensity of...

MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific and regulate many cellular processes. Neuroinflammation plays pivotal role in occurrence development of multiple central nervous system (CNS) diseases. The miRNAs enhance restrict neuroinflammatory signaling pathways CNS diseases is an emerging important research area, including neurodegenerative d...

Neuroactive testosterone metabolites synthesized by enzymes 5α-reductase and 3α/3β-hydroxysteroid oxidoreductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussed in this review, they exert a variety effects on myelination, brain maturation, neurotransmission, reproductive behavior, stress responses. The expression synthesis these well leve...

Microglial cells within the developing central nervous system (CNS) originate from mesodermic precursors of hematopoietic lineage that enter the nervous parenchyma from the meninges, ventricular space and/or blood stream. Once in the nervous parenchyma, microglial cells increase in number and disperse throughout the CNS; these cells finally differentiate to become fully ramified microglial cell...