Mr B first presented to an Accident and Emergency department in Bristol, having taken an overdose of fifty paracetamol tablets. He had became depressed over a period of six months, with biological features, including weight loss of two stones. There were no obvious precipitants. He was offered admission, but refused. Subsequently he was started on dothiepin and referred to outpatients. Further ...

Thirty patients with chronic pain due to osteoarthrosis (OA) of the knee were enrolled in a randomised double-blind cross-over trial of self-administered transcutaneous electrical nerve stimulation (TENS) and placebo TENS. Medication was standardised to paracetamol tablets only. As measured on visual analogue scales for pain relief 46% of patients responded to active therapy and 43% to placebo....

Aim. The choice of the qualitative and quantitative composition excipients to provide required mechanical strength disintegration time when developing a pharmaceutical in form orally disintegrating tablets (ODT) based on paracetamol N-acetyl-D-glucosamine. Materials methods. study object was pharmaceutically accepted used development solid dosage forms. To conduct statistical analysis experimen...

We analysed solid dose formulations retrieved from an amnesty bin at a London dance venue, into which visitors were required to discard illicit drugs and into which security staff place substances found during searches. We obtained a Home Office licence to analyse the contents of the bin, which were removed in the presence of a police officer and sealed in evidence bags. The data reported are f...

A hierarchical framework is proposed to address the issues of modeling different type of words in keyword spotting (KWS). Keyword models are built at various levels according to the availability of training set resources for each individual word. The proposed approach improves the performance of KWS even when no training speech is available for the keywords. It also suggests an easier way to co...

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Rapid separation and determination of acetaminophen and its hydrolysate with end-channel electrochemical (EC) detection integrated on a plastified poly(ethylene terephthalate) (PET)-toner microchip capillary electrophoresis (CE) system was investigated. In this separation and detection system, a Pt ultramicroelectrode integrated on a three-dimensional adjustor was used as working electrode. Fac...

AIM To determine the incidence of flare-up and the effect of age, gender, visit type, treatment duration, preoperative pain and intraoperative pain on flare-up in Nigerian adults. MATERIALS AND METHODS A total of 175 participants, aged 18 to 60 years with a necrotic central incisor, with or without preoperative pain, participated. They received postoperative paracetamol tablets and were asked...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...

Pain in ICU patients should be managed effectively and safely. Fentanyl and Paracetamol are used frequently in ICU. However experience using IV Paracetamol in the setting of critically ill patients is limited. We evaluated the analgesic effect and adverse reactions of intravenous Paracetamol compared to Fentanyl in ICU patients with mild to moderate pain. Forty patients in a general ICU were ra...