background and aims: the latency-associated transcript (lat) transcribed by latent herpes simplex virus type-1 in neuron cells are able to influence their host cell pathways. while the most of previous studies were focused on anti-apoptotic effects of lat, our investigation is making an effort to explore lat potency on cell cycle pathway in neuroblastoma cell lines. methods: the evaluation of l...

background: autoimmune type 1 diabetes mellitus is caused by t-cell mediated immune destruction of the insulin-producing β-cell in pancreatic islets of langerhans. specificity of the auto-antibodies and of the auto-reactive t-cells has been investigated, in which several auto-antigens were proposed. objective: to determine whether glutamic acid decarboxylase (gad) feeding would induce oral tole...

Several human acute myeloid leukemia cell lines were recently established. These lines provide model systems to study the control of differentiation in human myelogenous leukemia and, in a broader framework, the controls of normal myeloid development. The K562 line is composed of undifferentiated blast cells that are rich in glycophorin and may be induced to produce fetal and embryonic hemoglob...

The aim of this study is to search critical renin-angiotensin system (RAS) elements in myeloid leukemic cell lines. Human acute myeloid leukemia (AML) cell lines, KG-1 and HL-60, were cultured. We searched for the gene expression of the major RAS components in KG-1 and HL-60 cell lines by quantitative real-time polymerase chain reaction analysis (qRT-PCR). Angiotensin-converting enzyme I (ACE I...

The protection effect of KLT via iv infusion for leukopenia induced by harringtonine and CTX was studied. The mice were divided randomly into 7 groups: harringtonine 1 mg/kg (ip x 1, 5, 9) + KLT 12.5ml/kg (iv x 7), harringtonine 1mg/kg (ip x 1, 5, 9) + KLT 6.25 ml/kg (10 x 7), CTX 45mg/kg (ip x 1, 5, 9) + KLT 6.25 ml/kg (iv x 7), harringtonine 1 mg/kg (ip x 1, 5, 9), CTX 45mg/kg (ip x 1, 5, 9) ...

This study was carried out with the aim of detecting the dietary effects of isoflavone-genistein on hematological and immunological parameters in beluga, Huso huso in a 12-week feeding period. Five isonitrogenous (45% crude protein) and isoenergetic (19.5 MJ kg -1) diets were formulated to contain four graded levels of isoflavone-genistein, namely 0, 0.2, 0.4, 0.8 and 1.6 g kg-1 diet. Fish (ini...

turnips with a long history of usage, are helpful in preventing breast and prostate cancer, inflammation and body`s immune system dysfunction. in this study, we investigated the effects of chloroform, ethyl acetate and methanolic extracts of brassica rapa l. on cell-mediated immune response in mice. chloroform, ethyl acetate and methanolic extracts of b. rapa glands were prepared by maceration ...

Aim: Kefir is a probiotic/prebiotic drink with an exotic flavor, which has been traditionally produced fermented milk and kefir grains containing mixture of bacteria yeast. Cyclophosphamide (CPx), are generally limited due to numerous unwanted severe acute toxic side-effects. For this purpose, the cell-protective effects kefir, natural probiotic known for its antitumor antioxidant properties, o...