BACKGROUND Use of gentamicin is now limited due to its toxic effects, mainly on kidney and vestibular system. Herbal products including ginseng has been reported to possess protective effects against drugs induced nephrotoxicity in experimental animals. The current investigation was designed to evaluate the effects of ginseng on gentamicin induced nephrotoxicity. METHODS Eighteen male albino ...

BACKGROUND An increasing number of dialysis patients have returned to dialysis after renal graft loss, and the transition in disease state could likely be associated with reduced health related quality of life (HRQOL). Furthermore, gender differences in HRQOL have been observed in dialysis and kidney transplanted patients, but whether transition in disease state affects HRQOL differently in res...

The relationship of anaemia to the pathogenesis of cardiac abnormalities in patients with kidney disease has been the focus of much clinical and basic science research over the past two decades. There is extensive data to support the important contribution of anaemia to multiple morbidities in patients with kidney disease, not only cardiovascular disease (CVD). Anaemia impacts cognitive functio...

Background: The seed of breadfruit is a major food consumed in some parts Nigeria. It has been identified as an important leguminous that highly rich carbohydrates and protein with abundant minerals vitamins known to contain anti-nutrients. Aim: This study aims assess the possible toxicological effect feed fortified cooked, parboiled, grilled on liver kidney function parameters Wistar rats. Met...

BACKGROUND Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension and diabetes in recurrent kidney stone formers. METHODS A cross-sectional, case-control study comparing measures of kidney function, BMI and...

The kidneys play a dominant role in regulating the composition and volume of the extracellular fluid (ECF). They normally maintain a stable internal environment by excreting in the urine appropriate amounts of many substances. These substances include not only waste products and foreign compounds, but also many useful substances that are present in excess because of eating, drinking, or metabol...

OBJECTIVES To evaluate the internal consistency, validity, responsiveness, and minimal important difference of the Functional Status Score for the ICU, a physical function measure designed for the ICU. DESIGN Clinimetric analysis. SETTINGS Five international datasets from the United States, Australia, and Brazil. PATIENTS Eight hundred nineteen ICU patients. INTERVENTION None. MEASURE...

As part of human evolutionary development, many human organ systems have innate mechanisms to adapt to increased "work demand" or stress. This reserve capacity can be informative and is used commonly in cardiology to assess cardiac function (e.g., treadmill test). Similarly, the kidney possesses reserve capacity, which can be demonstrated in at least 2 of the following renal domains: glomerular...