AIM To investigate the therapeutic potential of tesevatinib (TSV), a unique multi-kinase inhibitor currently in Phase II clinical trials for autosomal dominant polycystic kidney disease (ADPKD), in well-defined rodent models of autosomal recessive polycystic kidney disease (ARPKD). METHODS We administered TSV in daily doses of 7.5 and 15 mg/kg per day by I.P. to the well characterized bpk mod...

objectives: the antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. herbal medicine can improve the antioxidant condition of renal tissue. cynodon dactylon (c. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. assessment of the whole plant decocti...

levels to normal, although we cannot exclude the possibility that prednisone, administered for immunosuppression, may have contributed to the decrease in plasma p-MSH concentration. The way that the kidney influences r-MSH metabolism is uncertain. Since the patients on haemodialysis who retain their kidneys pass little urine the difference in plasma p-MSH levels between those with kidneys and t...

objectives: nigella sativa (n. sativa) is an amazing herb which is used in traditional medicine for a wide range of illnesses including bronchial asthma, dysentery, gastrointestinal problems, as well as beneficial effect on blood lipids, lowering blood pressure, serum cholesterol, and triglycerides level. this study aimed to determine the toxic effect of n. sativa powder on the kidney function ...

The aim of this study was to investigate if dietary Chlorella vulgaris (chlorella) intake would be effective on cadmium (Cd) detoxification in rats fed dietary Cd. Fourteen-week old male Sprague-Dawley (SD) rats weighing 415.0 +/- 1.6 g were randomly divided into two groups and fed slightly modified American Institute of Nutrition-93 Growing (AIN-93G) diet without (n=10) or with (n=40) dietary ...

Introduction: Nowadays, nuclear medicine (NM) imaging indications in medical practice is raising. A practical step to get closer to the optimization rule is collecting data about patients’ exposure and definition of guidance levels. The aim of this study was definition of local reference level in Isfahan city. Materials and Methods: Questionnaires were given...

Cadmium is a modern toxic metal and is a by-product of zinc and lead mining and smelting, which are important sources of environmental pollution. In humans, the kidney is recognized as the most critical organ affected by chronic exposure to cadmium. The present study was designed to explore the renotoxic effects of intraperitoneal acute administration of CdCl2 (0.32 mg/kg b.w.) in albino mice. ...