objective: To compare the diagnostic performance of two height-independent equations used to calculate estimated glomerular filtration rate (eGFR), those of Pottel (eGFR-Pottel) and the British Columbia Children’s Hospital (BCCH; eGFR-BCCH), with the commonly used Schwartz equation (eGFR-Schwartz). study design: We externally validated eGFR-Pottel and eGFR-BCCH in a well-characterized pediatric...

BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...

The use of expanded criteria donors (ECD) has been proposed to help combat the discrepancy between organ availability and need. ECD kidneys are associated with delayed graft function (DGF) and worse long-term survival. The aim of this study is to evaluate the impact of pulsatile perfusion (PP) on DGF and graft survival in transplanted ECD kidneys. From January 2000 to December 2003, 4618 ECD ki...

Increased understanding of the pathophysiology of ischemic acute kidney injury in renal transplantation may lead to novel therapies that improve early graft function. Therefore, we studied the renal microcirculation in ischemically injured kidneys from donors after cardiac death (DCD) and in living donor kidneys with minimal ischemia. During transplant surgery, peritubular capillaries were visu...

Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K. Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys. Am J Physiol Regul Integr Comp Physiol 293: R1781–R1786, 2007. First published September 12, 2007; doi:10.1152/ajpregu.00439.2007.—We previously found that deletion of connexin 40 (Cx40) causes a misdirection of reninexpressing cells...

In the present work the influence of perfusion pressure on renal functions and renin release was studied before and after the blockade of thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors using isolated kidneys from 7-week-old genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) rats of the Lyon strain. Kidneys were single pass perfused with Krebs-Henseleit solution...

The relationship of vesicoureteric reflex (VUR) and renal scarring was studied in 94 children (188 kidneys) with proved urinary tract infection in a district general hospital. There were 61 girls and 33 boys, with nine girls and 17 boys aged less than 1 year, 31 girls and nine boys aged between 1 and 5 years, the remaining 28 children were over 5 years of age. All children had a micturating cys...

To examine the interrelation between renin mRNA levels, renin secretion, and blood pressure in rats, we clipped the left renal arteries of rats and measured renin mRNA levels in both kidneys, plasma renin activity, and blood pressure. One and 2 days after clipping, renin mRNA levels increased 3-fold and 4.3-fold in the stenosed kidney and were suppressed to 52% and 26% of controls in the intact...

Between June, 1984 and January 20, 1987, 69 kidney transplantations were performed in our department. All kidneys were acquired from living donors. 63% of the cases were high-risk MLC-positive (poorly matched), and all but one were from related sources. There were only five rejected kidneys, all of which occurred in kidneys from parent donors. 28 recipients received donor-specific transfus...