نتایج جستجو برای: kindler
تعداد نتایج: 219 فیلتر نتایج به سال:
Covering spaces of graphs have long been useful for studying expanders (as “graph lifts”) and unique games (as the “label-extended graph”). In this paper we advocate for the thesis that there is a much deeper relationship between computational topology and the Unique Games Conjecture. Our starting point is Linial’s 2005 observation that the only known problems whose inapproximability is equival...
The Friedgut–Kalai–Naor theorem, a basic result in the field of analysis of Boolean functions, states that if a Boolean function on the Boolean cube {0,1}n is close to a function of the form c0 +∑i cixi, then it is close to a dictatorship (a function depending on a single coordinate). We prove an analogous theorem for functions defined on the slice ([n] k ) = {(x1, . . . ,xn) ∈ {0,1}n : ∑i xi =...
Palmoplantar keratodermas (PPK) include a heterogeneous group of disorders with overlapping clinical features. The main aspect of PPK is thickening and hyperkeratosis of the palmar and plantar skin, that may be hereditary or acquired; diffuse, focal, or punctuate; and transgrediens or progrediens. PPKs are further distinguished by their mode of inheritance and by the presence of certain associa...
OBJECTIVE To present epidemiologic and clinical data from the Australasian Epidermolysis Bullosa (EB) Registry, the first orphan disease registry in Australia. DESIGN Observational study (cross-sectional and longitudinal). SETTING Australian private dermatology practice, inpatient ward, and outpatient clinic. PATIENTS Systematic case finding of patients with EB simplex, junctional EB (JEB...
R. Kanungo,1,* A. Prochazka,2,3 M. Uchida,1 W. Horiuchi,4 G. Hagen,5,6 T. Papenbrock,5,6 C. Nociforo,2 T. Aumann,7,2 D. Boutin,3 D. Cortina-Gil,8 B. Davids,9 M. Diakaki,10 F. Farinon,2,3 H. Geissel,2 R. Gernhäuser,11 J. Gerl,2 R. Janik,12 Ø. Jensen,13 B. Jonson,14 B. Kindler,2 R. Knöbel,2,3 R. Krücken,11 M. Lantz,14 H. Lenske,3 Y. Litvinov,2,15 B. Lommel,2 K. Mahata,2 P. Maierbeck,11 A. Musumar...
A 6-year-old patient was referred to our ophthalmology service because of an ocular deviation (esotropia) on the right eye for 3 years. Best-corrected visual acuity in right eye and 20/20 in left eye. According to the Krimsky test, the patient showed 15 prism dioptres esotropia in right eye. No changes were observed in biomicroscopy of both eyes and funduscopy of left eye was normal. An optical...
integrin (see figure). The binding of Kindlin to the integrin induces a conformational change in the integrin tail that facilitates the integrin to bind to another protein called Talin. Together, the binding of Kindlin and Talin to an integrin induces changes that allow the integrin to bind to its ligand. Until now, it appeared that the Kindlin-associated diseases—Kindler syndrome and leukocyte...
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