The structural stability of a peroxidase, a dimeric protein from palm tree Chamaerops excelsa leaves (CEP), has been characterized by high-sensitivity differential scanning calorimetry, circular dichroism and steady-state tryptophan fluorescence at pH 3. The thermally induced denaturation of CEP at this pH value is irreversible and strongly dependent upon the scan rate, suggesting that this pro...

application of chemical pesticides has increased significantly worldwide and has raised serious concerns about environmental pollutions. one of the encouraging trends to minimize pesticide risk is production of resistant plants containing toxic proteins against insect pests. considering the importance of purification and characterization of digestive enzymes in the production of resistant plant...

The well-known Cucker-Smale model is a macroscopic system reflecting flocking, i.e. the alignment of velocities in a group of autonomous agents having mutual interactions. In the present paper, we consider the mean-field limit of that model, called the kinetic Cucker-Smale model, which is a transport partial differential equation involving nonlocal terms. It is known that flocking is reached as...

Amyloid fibril formation involves nonfibrillar oligomeric intermediates, which are important as possible cytotoxic species in neurodegenerative diseases. However, their transient nature and polydispersity have made it difficult to identify their formation mechanism or structure. We have investigated the dimerization process, the first step in aggregate formation, by multiple molecular dynamics ...

We show that voltage-sensitive macromolecules can, by the application of the right type of external voltage fluctuations, be focused with great probability into a desired kinetic substate. As an illustration we consider an eight-state model of the Shaker K channel driven by dichotomous voltage fluctuations. This technique may provide a powerful new tool for the study of the kinetics of voltage ...

A unified description is put forward for the electron transmission through a molecule that is attached to two leads with the molecule being characterized by a single level to be populated by the transferred electrons. In deriving the expression for the current the Coulomb interaction is accounted for between the two extra electrons that may occupy the molecular level. The formation of two disti...

An organism's response to environmental and metabolic cues requires communication between transcription regulatory processes and "other" cellular events. In a number of biological control circuits, the communication is carried out by a single multifunctional protein that participates directly in transcription initiation and in at least one other cellular process. Structural studies suggest that...

Humans and other animals exchange gravitational potential energy (GPE) and kinetic energy (KE) of the center of mass during level walking. How effective is this energy exchange during downhill and uphill walking? Based on previous reports and our own reasoning, we expected that during downhill walking, the possibility for mechanical energy exchange would be enhanced and during uphill walking, t...