Androgen ablation is frequently used in conjunction with radiotherapy in the treatment of high-risk prostate cancer. Androgen ablation-induced cell kinetic changes could result in sub-additive (increased quiescence) or supra-additive (reduction in repopulation) interactions with radiotherapy. The cell kinetic changes were studied in R3327-G Dunning rat prostate tumors grown in vivo using double...

We discuss a new class of approaches for simulating multiscale kinetic problems, with particular emphasis on applications related to small-scale transport. These approaches are based on a decomposition of the kinetic description into an equilibrium part, which is described deterministically (analytically or numerically), and the remainder, which is described using a particle simulation method. ...

Pteridine reductase 1 (PTR1) is a novel broad spectrum enzyme of pterin and folate metabolism in the protozoan parasite Leishmania. Overexpression of PTR1 confers methotrexate resistance to these protozoa, arising from the enzyme's ability to reduce dihydrofolate and its relative insensitivity to methotrexate. The kinetic mechanism and stereochemical course for the catalyzed reaction confirm PT...

Parallel Molecular Dynamics simulations are conducted for describing growth on surfaces with different kind of roughness : a perfect ordered crystalline flat graphite surface, a disordered rough graphite surface and flat surface with an ordered localized defect. It is shown that disordered rough surfaces results in a first step to reduction of the sticking coefficient, increased cluster density...

In this note, we prove the generic Kobayashi volume measure hyperbolicity of singular directed varieties (X,V ), as soon as the canonical sheaf KV of V is big in the sense of Demailly.

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral β-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic β-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.

Mixed-metal supramolecular complexes have been designed that photochemically absorb solar light, undergo photoinitiated electron collection and reduce water to produce hydrogen fuel using low energy visible light. This manuscript describes these systems with an analysis of the photophysics of a series of six supramolecular complexes, [{(TL)₂Ru(dpp)}₂RhX₂](PF₆)₅ with TL = bpy, phen or Ph₂phen wi...

This paper presents the design, implementation and evaluation of “dBug” – a tool that leverages manual instrumentation for systematic evaluation of distributed and concurrent systems. Specifically, for a given distributed concurrent system, its initial state and a workload, the dBug tool systematically explores possible orders in which concurrent events triggered by the workload can happen. Fur...

In this paper, a recently proposed dimensionality reduction method called Twin Kernel Embedding (TKE) [10] is applied in 2-dimensional visualization of protein structure relationships. By matching the similarity measures of the input and the embedding spaces expressed by their respective kernels, TKE ensures that both local and global proximity information are preserved simultaneously. Experime...

The objects of this investigation were the comparative kinetic analysis of the NiO and NiCl2 reduction by hydrogen during an induction period and elimination of the calcination during the synthesis of Ni/Al2O3 catalysts. The effect of temperature and time on NiO and NiCl2 reduction degrees was studied. Avrami I equation was selected as the most favorable kinetic model and used to determine acti...