PURPOSE To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men. MATERIALS AND METHODS Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a ...

Introduction: In order to clarify the characteristics of different administration routes and to optimize the dosage, carnitine kinetics was investigated under oral and intravenous supplementation. Methods: Lcarnitine was administered orally (900mg) for 12months, intravenously (1000 mg) for 3months and (500mg) for 3months sequentially in 18 chronic hemodialysis patients. Plasma free and acyl car...

It is well documented that high therapeutic doses of oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IFO), are associated with cardiomyopathy. This study investigated whether oxazaphosphorines alter the expression of organic cation/carnitine transporter (OCTN2) and antioxidant genes and if so, whether these alterations contribute to CP and IFO-induced cardiotoxicity. Adult male Wistar ...

BACKGROUND l-Carnitine is the essential endogenous factor for the transport of long-chain fatty acids from the cytoplasm to within the mitochondrion where the β-oxidation process takes place. l-Carnitine is a superoxide scavenger and an antioxidant that possesses an anti-ischemic action and a stabilizing effect on cell membranes. It may be of help in liver ischemia reperfusion injury. RESULTS r...

An experiment was conducted to study the effects of soybean, linseed and sunflower oil (various sources of fatty acids) with and without L-carnitine supplements (0 and 50 mg kg-1) on performance, blood biochemical parameters and carcass traits of Japanese quail. One hundred and ninety-two of 7-day old female Japanese quail were randomly assigned to 6 dietary treatments with 4 replicates and fed...

Jacyno E., A. Kołodziej, M. Kamyczek, M. Kawęcka, K. Dziadek, A. Pietruszka: Effect of L-Carnitine Supplementation on Boar Semen Quality. Acta Vet Brno 2007, 76: 595-600. The effect of addition of L-carnitine on boar semen quality was studied in 5 Pietrain boars at age 1.5 2.0 years. The boars received 500 mg of L-carnitine per day for 5 weeks. During this period, their ejaculates were collecte...

We investigated whether chronic intravenous administration of l-carnitine could improve myocardial fatty acid imaging in patients on maintenance hemodialysis. We enrolled 72 hemodialysis patients who had impaired myocardial fatty acid imaging and left ventricular dysfunction not based on coronary lesion. l-Carnitine (1,000 mg) was intravenously administered after dialysis for 1 year to 36 parti...

The present study was conducted to examine the effects of L-carnitine on pulmonary hypertensive response in broiler chickens reared at high altitude and exposed to hypobaric hypoxia. A total of 192 day-old male broilers (Cobb 500) were randomly assigned to 4 treatments and 4 replicates of 12 chicks. A basal diet composed of mainly corn and soybean meal was formulated and served as a control. Th...

OBJECTIVE To report a case of vaccine-induced Graves' disease successfully managed with L-carnitine and propranolol and without antithyroid drugs (ATDs). ATDs sometimes need to be used at low doses or can be contraindicated/refused. One of the ancillary compounds available is L-carnitine. L-carnitine is a naturally occurring quaternary amine, which acts by impairing thyroid hormone access to th...

L-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where β-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H₂O₂), were characterized with lower levels of L-carnitine, diminished β-oxidation, and increased lipid accumulation...