The standard Support Vector Machine (SVM) minimizes the hinge loss function subject to the L2 penalty or the roughness penalty. Recently, the L1 SVM was suggested for variable selection by producing sparse solutions (Bradley and Mangasarian, 1998; Zhu et al., 2003). These learning methods are non-adaptive since their penalty forms are pre-determined before looking at data, and they often perfor...

To determine the role of the hormone prolactin and its receptor on the differentiation, growth, and metabolic activity of cells of bone marrow origin, prolactin receptor expression was assessed in bone marrow stromal cells. Using reverse transcription - polymerase chain reaction, BMS2 cells, a bone marrow stromal cell line, were shown to express prolactin receptors following adipocyte different...

objective(s):  infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. recombinant dna technology allows expression of the l1 major capsid protein of hpv in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (vlp). vlps are non-infectious, highly immunogenic and can elicit neutralizing a...

This paper presents an examination of the variable lexical labels used by listeners to identify 16 social affective expressions in Japanese language, in audiovisual presentations. A free-labeling task allows an open approach to variability in the perception of social affects, that is constrained by pre-defined force-choice paradigms. 27 L1 Japanese listeners participated in the experiment. Subj...

Leptin is a key regulator of energy intake and expenditure. This peptide hormone is expressed in mouse white adipose tissue, but hardly expressed in 3T3-L1 adipocytes. Using bisulfite sequencing, we found that CpG islands in the leptin promoter are highly methylated in 3T3-L1cells. 5-azacytidine, an inhibitor of DNA methyltransferase, markedly increased leptin expression as pre-adipocytes matur...

The speech of late second language (L2) learners is generally marked by an accent. The dominant theoretical perspective attributes accents to deficient L2 perception arising from a transfer of L1 phonology, which is thought to influence L2 perception and production. In this study we evaluate the explanatory role of L2 perception in L2 production and explore alternative explanations arising from...

To establish an edible HPV16 vaccine, we constructed a recombinant HPV16 L1-expressing Schizosaccharomyces pombe yeast strain (HPV16L1 yeast). A preliminary study revealed that freeze-dried yeast cells could be delivered safely, and were digested in the mouse intestine. The freeze-dried HPV16 L1 yeast was administered orally as an edible vaccine, with or without the mucosal adjuvant heat-labile...

Abstract Bringing together lines of research from sentence processing and lexical access, this empirical study investigates the interplay between (grammatical gender) syntactic (word order) cross-linguistic overlap in L2 German. Eighty-six L1 Spanish-L2 German thirty-six monolingual adults completed a self-paced reading task with noun phrases (NPs) manipulated by L1-L2 gender congruency (congru...

Ribosomal frameshifting occurs when a ribosome slips a few nucleotides on an mRNA and generates a new sequence of amino acids. Programmed -1 ribosomal frameshifting (-1PRF) is used in various systems to express two or more proteins from a single mRNA at precisely regulated levels. We used single-molecule fluorescence resonance energy transfer (smFRET) to study the dynamics of -1PRF in the Esche...