نتایج جستجو برای: l1 use
تعداد نتایج: 1775965 فیلتر نتایج به سال:
Antibodies against programmed death (PD) pathway are revolutionizing cancer immunotherapy. Currently five antibodies against PD-1/PD-L1 have been approved. The clinical use of these antibodies is rapidly expanding. Incorporation of PD antibodies into chemotherapy regimens is in active clinical investigations. The combination of pembrolizumab with carboplatin and pemetrexed has been approved for...
We defend that bilingual lexicons automatically extracted from parallel corpora, whose entries have been meanwhile validated by linguists and classified as correct or incorrect, should constitute a specific parallel corpora. And, in this paper, we propose to use word-to-word translations to learn morph-units (comprising of bilingual stems and suffixes) from those bilingual lexicons for two lang...
Murine 3T3-L1 adipocytes are widely used as a cellular model of obesity. However, whereas transfection of 3T3-L1 preadipocytes is straightforward, ectopic gene expression in mature 3T3-L1 adipocytes has proved challenging. Here, we used the pSLIK vector system to generate stable doxycycline-inducible expression of the liver-enriched inhibitor protein isoform of CCAAT/enhancer binding protein b ...
This study examined the role of the native language (L1) transfer in a non-native language (L2) acquisition of the there-insertion construction at the syntax-semantics interface. Specifically, the study investigated if Mandarin EFL learners would make overgeneralization errors in the situation where an L1 argument structure constitutes a superset of its L2 counterpart. Verbs of existence and ap...
Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical responses, with highest likelihood of response seen in patients whose tumour or immune cells express PD-L1 before thera...
During reading we have to process the syntactic structure of the sentences in front of us. Thus, if we process sentences in two different languages, for example German and English, do we access and use the same syntactic information for both languages if the structures are similar? In this study we show that on the neural level sentences in the first and in the second language (L1 and L2) are p...
Speakers who live in an L2 environment for an extended period of time often experience change in the way in which they use their L1, a process referred to as L1 attrition. This article provides an overview of language attrition phenomena at various linguistic levels. However, attrition cannot be trivially or linearly related to factors such as the frequency of use of the L1. It is argued here t...
Background: Blocking the PD1-PD-L1 interaction has been shown to stimulate anti-tumour responses. Although antibody-based drugs targeting either PD-1 or PD-L1 are approved, small molecule inhibitors of currently in development. A subset these induce loss cell surface a time- and concentration-dependent manner. INCB090244 is that previously bind disrupt PD-L1/PD-1 interaction. Materials Methods:...
The use of language as a universal tool for communication and interaction is the backbone human society. General sociocultural milieu specific contextual factors can strongly influence various aspects linguistic experience, including acquisition respective internal neurolinguistic processes. This particularly relevant in case bilingualism, which encompasses diverse set experiences, greatly infl...
Recent interest in the use of L1 regularization in the use of value function approximation includes Petrik et al.’s introduction of L1-Regularized Approximate Linear Programming (RALP). RALP is unique among L1-regularized approaches in that it approximates the optimal value function using off-policy samples. Additionally, it produces policies which outperform those of previous methods, such as ...
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