The ability to study interactions among biomolecules, to observe the activity of cells, and to detect analytes specifically from bodily fluids, manufacturing processes, or environmental samples are cornerstones of life science research, pharmaceutical discovery, medical diagnosis, and food/water safety assurance. These capabilities and many others are enabled by the ability to perform biochemic...

Label-free cell analysis is essential to personalized genomics, cancer diagnostics, and drug development as it avoids adverse effects of staining reagents on cellular viability and cell signaling. However, currently available label-free cell assays mostly rely only on a single feature and lack sufficient differentiation. Also, the sample size analyzed by these assays is limited due to their low...

Utilizing its integrated camera as a spectrometer, we demonstrate the use of a smartphone as the detection instrument for a label-free photonic crystal biosensor. A custom-designed cradle holds the smartphone in fixed alignment with optical components, allowing for accurate and repeatable measurements of shifts in the resonant wavelength of the sensor. Externally provided broadband light incide...

probability of this quantum receiver did not fall below 10–4 is due to experimental limitations; in particular, the visibility of the interferometer at the beamsplitter used in the displacement operation and the detection efficiency of the singlephoton detector were major sources of imperfection. Imperfect visibility causes errors in photon counts even when a correct displacement operation is c...

Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and other applications due to low cost, ease of miniaturization, and label-free operation. Unlabeled DNA and protein targets can be detected by monitoring changes in surface impedance when a target molecule binds to an immobilized probe. The affinity capture step leads to challenges shared by all label...

Screening of biochemical interactions becomes simpler, less expensive, and more accurate when labels, such as fluorescent dyes, radioactive markers, and colorimetric reactions, are not required to quantify detected material. SRU Biosystems has developed a biosensor technology that is manufactured on continuous sheets of plastic film and incorporated into standard microplates and microarray slid...

retention time reproducibility of the Waters nanoACQUITY UPLCTM System, coupled with the elevated resolution and mass measurement accuracy afforded by the Micromass® Q-Tof PremierTM mass spectrometer, which provides the selectivity and specificity necessary to allow ions to be identified and correlated across identically prepared control and experimental sample sets. Waters® Protein Expression ...

Anodization of Al is used to produce optically smooth porous alumina (Al(2)O(3)) films with pores approximately 60 nm in diameter and approximately 6 mum deep. The capture protein, protein A, is adsorbed to the pore walls by noncovalent, electrostatic interactions, and thin film interference spectroscopy is used to detect binding of immunoglobulin (IgG). The porous alumina films are stable agai...

This study was undertaken to quantitate a single virus suspension in culture medium without any pre-processing. The electrical capacitance per virus particle was used to identify the kind of virus present by measuring the suspension (virus plus medium) capacitance, de-embedding the medium contribution, and dividing by the virus count. The proposed technique is based on finding the single virus ...