نتایج جستجو برای: lactam antibiotics among gram
تعداد نتایج: 1278677 فیلتر نتایج به سال:
Background: The increasing use of β-lactam antibiotics in clinics for the treatment of different bacterial infections since early 1980s has led to increased rates of resistant bacteria isolated from patients. One of the problems in the treatment of nosocomial infections is related to resistant bacteria such as Enterobacter cloacae due to cross resistance through extended-spectrum beta-lactamase...
Background & objective: Beta-lactam antibiotics resistance specifically Imipenem and Meropenem, the last choices of treatment, causes fatal events in patients with P.aeruginosa infection. The aim of this study was to detect the VIM and IMP of metallo-beta-lactamase genes in 103 isolates of P. aeruginosa in two Iranian hospitals. <strong...
Penicillin G acylase (PGA; EC 3.5.1.11) is a hydrolytic enzyme that acts on the side chains of penicillin G, cephalosporin G and related ntibiotics to produce the -lactam antibiotic intermediates 6-amino penicillanic acid (6-APA) and 7-amino des-acetoxy cephalosporanic acid 7-ADCA), with phenyl acetic acid (PAA) as a common by-product. These antibiotic intermediates are among the potential buil...
Penicillin-binding proteins (PBPs) are enzymes responsible for the polymerization of the glycan strand and the cross-linking between glycan chains as well as the target proteins for β-lactam antibiotics. Mutational alterations in PBPs can confer resistance either by reducing binding of the antibiotic to the active site or by evolving a β-lactamase activity that degrades the antibiotic. As no sy...
CONTEXT Beta-lactamases are bacterial enzymes that protect microorganisms from the lethal effects of β-lactam antibiotics. The production of beta-lactamases is the most important mechanism of resistance to these antibiotics, especially in Gram-negative bacteria. OBJECTIVE Review the magnitude of the problem of extended-spectrum beta-lactamases (ESBL) in the urological setting and present the ...
Following the discovery of the first analog of penicillin by A. Fleming (1929), the ┚-lactam antibiotics are still a developing group of chemotherapeutics and are used in treatment of majority of diseases with bacterial etiology. ┚-lactam antibiotics have a broad spectrum of antibacterial activity, favourable pharmacokinetic parameters and low side effects. In ┚lactam therapy two main problems ...
background vancomycin-resistant enterococci (vre) are the most common nosocomial pathogen worldwide. colonization with vre can lead to serious infection, some of which e.g. vre sepsis can be fatal. because vre are dangerous important pathogens, we aimed to determine the prevalence of vre among patients admitted in infectious, icu and surgery wards in a referral teaching hospital in isfahan, ira...
The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the β-lactam antibiotics by methicillin-resistant Staphylococcus aureus (MRSA). The high-molecular mass penicillin binding proteins of bacteria catalyze in separate domains the transglycosylase and transpeptidase activities required for the biosynthesis of the peptidoglycan polymer that com...
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