Interspecies platelet immunizations among marmosets lead to antibody formation to the donor platelets and a profound thrombocytopenia, which when associated with anemia may result in death of the animal. This actively induced immunologic thrombocytopenia closely resembles two clinical disease entities manifesting autoimmune thrombocytopenia, posttransfusion purpura and idiopathic thrombocytopen...

Understanding how tumours develop resistance to chemotherapy is a major issue in oncology. When treated with temozolomide (TMZ), an oral alkylating chemotherapy drug, most low-grade gliomas (LGG) show an initial volume decrease but this effect is rarely long lasting. In addition, it has been suggested that TMZ may drive tumour progression in a subset of patients as a result of acquired resistan...

High-dose intravenous gammaglobulin (lVlgG) was given to 1 2 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239.5OO/ zl (range 23.000-790,000). A concomitant lgG Fc r...

Focal brain lesions can alter the morphology and function of remote brain areas. When the damage is inflicted more slowly, the functional compensation by and structural reshaping of these areas seem to be more effective. It remains unclear, however, whether the momentum of lesion development also modulates the functional network topology of the remote brain areas. In this study, we compared res...

A high correlation (r 0.85) normally exists between the concentration of albumin and of lgG in cerebrospinal fluid (CSF). The correlation is still better (r = 0.96) if the concentrations of the two proteins are also measured in plasma and the CSF/ plasma ratios compared for albumin and lgG. The scatter diagram for these ratios in persons without disease of the nervous system is most useful as a...

Since the least general generalization LGG of strings may cause an over generalization in the generalization process of clauses we propose a speci c least general generalization SLGG of strings to reduce over generalization To create a SLGG of two strings rst a minimal match sequence between these strings is found A minimal match sequence of two strings consists of similarities and di erences t...