Previous studies showed that hydrolysates of β-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, sugges...

Introduction Allergy to cow’s milk (CM) proteins has as major allergens caseins (60%), b-lactoglobulin (9%) and a-lactalbumin (4%). Thermal processes for milk industrialization include: pasteurization (low: 63 ° C for 30 min or High: 72 ° C for 15 seconds), UHT heating (145 ° C for 1-2s) and sterilization (115 ° C for 15 min).It’s accepted that these processes denature milk proteins in differen...

Background Aluminum hydroxide (Al(OH)3) is a widely used adjuvant for induction of experimentally Th2 responses in animals and hence has been used for examination of food protein allergenicity. Further Al(OH)3 is used as an adjuvant for subcutaneous allergy vaccines. In the present study we investigated the impact of the use of Al(OH)3 on the antibody specificity to the cow’s milk allergens b-l...

Background Atopic dermatitis is a multifactorial disease associated with elevated production of IgE and sensitization to multiple food and inhalant allergens.The aim of this study was to assess the levels of total serum IgE (IgE) and specific IgE (sp IgE ) for Dermatophagoides pteronyssinus (Dp), Blomia tropicalis (Bt), egg white, casein, alpha-lactalbumin and beta-lactoglobulin in patients wit...

background: classification of molar gestation into complete hydatidiform mole (chm) and partial hydatidiform mole (phm) is done according to clinical, ultrasonographic, histologic and genetic criteria. however, making a distinction between chm and phm using histologic criteria alone may be difficult and several studies have shown that misclassifications are frequent, even for experienced pathol...

objectives: this current research was conducted in order to analyze the molecular characterization of isolated cryptosporidium spp. in the southwest of iran. materials and methods: in this survey, 390 fecal samples were collected from immunocompromised individuals and children under five-years-of-age. parasitic infection was evaluated using wet mount preparation, formalin ether, a modified acid...