Teams in this unit aim at elucidating the regulation of mechanisms that are crucial to the maintenance of genome integrity, like DNA replication, repair and recombination, as well as the role of cell cycle checkpoints and non-coding RNAs in genome and epigenome maintenance. Experimental models include yeast, mammalian and human cell lines, mutant mouse models and tumour samples. A large variety...

Enterprise Architecture Management (EAM) is a common practice in organizations that need to have a model of how their business relates to the supporting IT-landscape in order to make informed decisions to enhance the enterprise architecture (EA). Creating and maintaining such an EA model is an expensive and time consuming but crucial task in today’s organizations. This has been recognised by bo...

development of remote sensing (rs) and gis techniques and that of landscape metrics in the late 1980s have caused to introduce a new dimension in the landscape ecology arena (the relationship between spatial patterns and ecological processes). however, scale dependence of some of landscape metrics and rs systems of different spatial resolution has resulted in particular attention into selection...

For more than a century, scientists have investigated the natural history of plague, a highly fatal disease caused by infection with the gram-negative bacterium Yersinia pestis. Among their most important discoveries were the zoonotic nature of the disease and that plague exists in natural cycles involving transmission between rodent hosts and flea vectors. Other significant findings include th...

the notion of sustainable development has rapidly gained considerable attention since the lastdecades of the twentieth century. it has become a locus for global paradigm shift on environment and development issues particularly after rio conference in 1992. the comparative analysis of agenda 21 and major un documents, mdg, and rio+20 as well as some major sources are made to provide a context fo...

Sewall Wright’s adaptive landscape is the most influential heuristic in evolutionary biology. Wright’s biographer, Provine, criticized Wright’s adaptive landscape, claiming that its heuristic value is dubious because of deep flaws. Ruse has defended Wright against Provine. Ruse claims Provine has not shown Wright’s use of the landscape is flawed, and that, even if it were, it is heuristically v...

Fractal terrains provide an easy way to generate realistic landscapes. There are several methods to generate fractal terrains, but none of those algorithms allow the user much flexibility in controlling the shape or properties of the final outcome. A few methods to modify fractal terrains have been previously proposed, both algorithm-based as well as by hand editing, but none of these provide a...

This paper presents the creation of a a visual environment for exploring landscape patterns and changes to such patterns over time. Dynamic landscape patterns can involve both spatial and temporal complexity. Exploration of spatio-temporal landscape patterns should provide the ability to view information at di erent scales to permit navigation of a vast amount of information in a manner that fa...