Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...

Role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. Cases of overexpression of p53 and Ki67 proteins were investigated in 19 ocular squamous cell carcinomas (OSCC) in dairy cows. Microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, G0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

human papillomavirus (hpv) dna has been identified in esophageal carcinomas. however, the incidence of hpv varies significantly in different geographical locations. in this study, neoplasms from turkmen sahra, a region in golestan province in northeast part of iran, with a high incidence of squamous cell carcinoma were analyzed for the presence of hpv dna. turkmen sahra is located in the cancer...

background: ovarian cancer is the most common cause of cancer death worldwide. incidence of ovarian cancer is more common in postmenopausal women. premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. case presentation: the patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was mad...

introduction: primary small cell carcinoma of theesophagus (pscec) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. the lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. s...

purpose: to determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in fars province, south of iran. methods: histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of khalili hospital, shiraz, iran was reviewed from april, 2009 to july, 2013. the histopathologic diagnoses were categorized into benign, ...

ocular surface may be involved by different neoplastic lesions ranging from benign to highly malignant. recognition of risk factors, clinical presentations, pathology, and different therapeutic modalities is essential for selecting an appropriate approach. this article deals with the proper approach to ocular surface squamous neoplasia (ossn) including conjunctival/corneal intraepithelial neopl...

introduction: nasopharyngeal carcinoma is one of the most common malignancies in the head and neck region and radiotherapy is its treatment of choice. in spite of the fact that it is widely used, due to the presence of many sensitive organs or tissues in this region, patients may suffer from a wide range of side effects. one such sensitive tissue is the spinal cord. if the absorbed dose to spin...