Laser-induced fluorescence measurements of OH have been performed in an atmospheric stoichiometric CH(4)/air flame and in a highly sooting propane flame. The measurements were realized with a single 6-nsec pulse from a frequency-doubled dye laser pumped by a Nd:YAG laser and with a spatial resolution of ~25 microm. This was achieved by imaging through a suitably chosen filter set a section of t...

The long term goal of this program is to advance understanding of distributed laser line scan (DLLS) imaging and networking techniques and their applicability to Navy missions which utilize multiple UUVs in support of littoral operations. The planned three year outcome of the work is to provide a validated radiative transfer simulation suite which can allow underwater laser imaging and communic...

We present in vivo human fundus imaging using a fiber-based confocal scanning laser ophthalmoscope (SLO). Spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) utilizes a spectral encoding technique in one dimension, combined with single-axis lateral scanning, to create video-rate reflectivity maps of the fundus. This implementation of the SLO allows for high-contrast high-resoluti...

Photoacoustics (PA) is a new imaging modality based on the generation of ultrasound by laser irradiation [1]. When a nanosecond pulsed laser irradiates biological tissue, thermo-elastic expansion will cause ultrasonic waves that can be used for imaging by mapping the amount of light absorption by using ultrasound transducers. PA imaging is real-time imaging that combines high resolution and rel...

In this study, we investigate the effects of CO2 laser polishing on microscopic structures fabricated by femtosecond laser assisted carving (FLAC). FLAC is the peripheral laser irradiation of 2.5D structures suitable for low repetition rate lasers and is first used to define the microwell structures in fused silica followed by chemical etching. Subsequently, the bottom surface of patterned micr...

Polarimetric Imaging: From Optical Coherence Tomography to Laser Radar

Purpose Subthreshold, nanosecond pulsed laser treatment shows promise as a treatment for age-related macular degeneration (AMD); however, the safety profile needs to be robustly examined. The aim of this study was to investigate the effects of laser treatment in humans and mice. Methods Patients with AMD were treated with nanosecond pulsed laser at subthreshold (no visible retinal effect) ene...

Second-harmonic-generation (SHG) microscopy is an interesting new tool for observing dermal collagen fiber in skin. However, conventional SHG microscopy using a mode-locked Ti:sapphire laser suffers from low penetration depth and a slow image acquisition rate caused by scattering and absorption in tissue, making it difficult to use for in vivo applications on human skin. We develop an SHG micro...