Surface-enhanced laser desorption/ionization (SELDI) time of flight (TOF) is a mass spectrometry technology for measuring the composition of a sampled protein mixture. A mass spectrum contains peaks corresponding to proteins in the sample. The peak areas are proportional to the measured concentrations of the corresponding proteins. Quantifying peak areas is difficult for existing methods becaus...

A prismless ultrafast Cr4*:YAG laser has been designed and constructed. Intracavity dispersion in this laser is compensated through the use of double-chirped mirrors, in contrast to previous work, which used fused silica prisms. The resonator design for Kerr lens modelocking has been optimized through the use of numerical simulation programs, based on the ABCD transfer matrix formalism. Pulses ...

The new techniques in seismic design of structures are usually attributed to high damping ratios. In such systems, the assumption of classical (i.e. proportional) damping is not valid and in most cases they should be considered as Non-classical systems. Since the analytical tools for studying the behavior of such structures are not easily available, the present work attempts to find the limits,...

We present a novel nonparametric Bayesian approach based on Lévy Adaptive Regression Kernels (LARK) to model spectral data arising from MALDI-TOF (Matrix Assisted Laser Desorption Ionization Time-of-Flight) mass spectrometry. This model based approach provides identification and quantification of proteins though model parameters that are directly interpretable as the number of proteins, mass an...

The new techniques in seismic design of structures are usually attributed to high damping ratios. In such systems, the assumption of classical (i.e. proportional) damping is not valid and in most cases they should be considered as Non-classical systems. Since the analytical tools for studying the behavior of such structures are not easily available, the present work attempts to find the limits,...

In a high-resolution MALDI-TOF mass spectrum, a peptide produces multiple peaks, corresponding to the isotopic variants of the molecules. An overlap occurs when two peptides appear in the vicinity of the mass coordinate, resulting in the difficulty of quantifying the relative abundance and the exact masses of these peptides. To address the problem, two factors need to be considered: (1) the var...

The first use of MALDI-TOF MS in the study of the products of RLi (R = Me, Bu) initiated oligomerisation of P[double bond, length as m-dash]C bonds is reported. These studies may be considered as models for analogous polymerisation reactions. The detected linear products with R-P and C-H end-groups are consistent with a chain growth mechanism similar to that known for olefins. Interestingly, th...