Saccadic eye movements and the adaptive control of their amplitudes were examined in patients with Wallenberg's lateral medullary syndrome. Half of the patients had permanent saccadic dysmetria. Their primary saccades had asymmetric amplitudes: those made in response to an ipsilateral target step (i.e. to the lesion side) tended to be hypermetric and saccades made in response to a contralateral...

Central alveolar hypoventilation syndrome (CAHS) is a rare and potentially fatal condition. However, respiratory care for patients with CAHS caused by lateral medullary infarction (CAHS-LMI) remains an important unsolved problem. We describe 2 patients with CAHS-LMI and review the case reports for 17 previously described patients. Patient 1 was a 78-year-old man who was referred to our hospital...

HYPOTHESIS Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis. DESIGN Retrospective analysis. SETTING Tertiary referral center at a university hospital. PATIENTS Two hundred fifteen consecutive patients who underwent systematic central ...

Polydipsia and polyuria associated with traumatic spinal cord injury (SCI) are rare consequences. The hypothetical pathophysiological mechanisms involve mild brain (TBI) and/or vagus dysfunction injury. In a retrospective study of 11 patients, we investigated associations between polydipsia-polyuria syndrome various clinical therapeutic factors: medullary section syndrome, neurological level, m...

Granulomatosis with polyangiitis (GPA, formerly Wegener granulomatosis) is a vasculitis with various organ involvement. There have been a few cases of CNS stroke and rare cases of lateral medullary infarction (LMI) as a manifestation of GPA. Also there have been reports of sinuses, nose and laryngeal masses mistakenly referred as carcinomas and subsequently GPA was diagnosed in their pathologic...

MEN IIB: It is associated with pheochromocytoma, mucosal ganglioneuromas, and marfanoid habitus. This syndrome also presents medullary carcinoma and pheochromocytoma, but only rarely will have hyperparathyroidism. Inheritance isautosomal dominant as in MEN IIA. MEN IIB patients usually get medullary carcinomaearly in life, diagnosed in infancy or early childhood before their 30s, and males andf...

■ We examined the normal development of intrinsic functional connectivity of the default network (brain regions typically deactivated for attention-demanding tasks) as measured by resting-state fMRI in children, adolescents, and young adults ages 8–24 years. We investigated both positive and negative correlations and employed analysis methods that allowed for valid interpretation of negative co...

BACKGROUND Spontaneous nystagmus caused by dorsolateral medullary infarction may be of vestibular origin. OBJECTIVES To test if imbalance of the central pathways of the semicircular canals contributes to spontaneous nystagmus in dorsolateral medullary syndrome. METHODS We examined four patients with dorsolateral medullary syndrome and recorded spontaneous nystagmus binocularly at gaze strai...

Ectopic production of CRH by a medullary thyroid carcinoma or its metastases is a rare cause of ectopic Cushing's syndrome (ECS). We report a 45-year old male with medullary thyroid carcinoma (MTC), who, 24 years following the initial diagnosis, presented with clinical and biochemical evidence of an ACTH dependent Cushing's syndrome. Rapid deterioration of his clinical condition and elevated co...