Aziridine-containing compounds have been of interest as anticancer agents since late 1970s. The design, synthesis and study of triaziquone (TZQ) analogues with the aim of obtaining compounds with enhanced efficacy and reduced toxicity are an ongoing research effort in our group. A series of bis-type TZQ derivatives has been prepared and their cytotoxic activities were investigated. The cytotoxi...

The present study evaluates the insecticidal activity of two essential Oil (EOs) mint (Mentha arvensis), and ajwain (Carum capyicum) against pulse beetle (Callosobruchus chinensis) (L). Contact toxicities these were evaluated using parameters lifecycle like total development period, numbers eggs laid, adult emergence longevity. Along with detoxification enzyme inhibition activities acetyl choli...

twenty six rhizobium strains were isolated from root nodules of sesbania sesban (l.) merr. collected from different regions of andhra pradesh. all the 26 rhizobium strains produced indole acetic acid (iaa), but maximum amount was produced by only five strains in yeast extract mannitol  (yem) medium supplemented with l-tryptophan. the strains were found to elaborate maximum iaa when fed with 2.5...

Light chain amyloidosis (AL) involves overproduction of amyloidogenic light chain proteins (LC) leading to heart failure, yet the mechanisms underlying tissue toxicity remain unknown. We hypothesized that LC induces endothelial dysfunction in non-AL human microvasculature and apoptotic injury in human coronary artery endothelial cells (HCAECs). Adipose arterioles (n = 34, 50 ± 3 yr) and atrial ...

Laboratory diagnosis of human respiratory syncytial virus (hRSV) infections has traditionally been performed by virus isolation in cell culture and the direct fluorescent-antibody assay (DFA). Reverse transcriptase PCR (RT-PCR) is now recognized as a sensitive and specific alternative for detection of hRSV in respiratory samples. Using the LightCycler instrument, we developed a rapid RT-PCR ass...

The carbon clearance ability of female ddY mice was markedly reduced by feeding with a high fat-low carbohydrate (HFLC) diet for 8 weeks. The reduced clearance ability was restored by a single intraperiotoneal (i.p.) injection with heat-killed Lactobacillus casei (YIT 9018) cells (LC 9018). The i.p. injection of LC 9018 into the HFLC diet-fed mice led to a remarkable enhancement of nonspecific ...

Within T cell–rich areas of secondary lymphoid organs, interdigitating dendritic cells recruit antigen-specific T cells that then induce B cells to secrete Igs. This study investigates the possible role(s) of dendritic cells in the regulation of human B cell responses. In the absence of exogenous cytokines, in vitro generated dendritic cells (referred to as Dendritic Langerhans cells, D-Lc) ind...