Langerhans cell histiocytosis (LCH) is a rare disease and disease confined to the lymph nodes is even more uncommon. Fine needle aspiration (FNA) cytology of LCH of the lymph nodes has rarely been described. A case study of LCH of the lymph nodes in a 23-year-old man is presented. FNA smears showed high cellularity composed of many isolated Langerhans cells (LCs) with nuclear grooves admixed wi...

Cerebral Langerhans cell histiocytosis (LCH) is a rare granulomatous disorder which may be primary, secondary and solitary or multiple. Central Nervous System (CNS) involvement without a systemic disease is very rare. The most frequent involvement of the cerebral LCH is in the cranial bones and the hypothalamic-pituitary axis (HPA). Cerebral LCH without involvement of HPA is very rare. We have ...

Langerhans cell histiocytosis (LCH) has a broad spectrum of clinical behaviors; some cases are self-limited, whereas others involve multiple organs and cause significant mortality. Although Langerhans cells in LCH are clonal, their benign morphology and their lack (to date) of reported recurrent genomic abnormalities have suggested that LCH may not be a neoplasm. Here, using 2 orthogonal techno...

SUMMARY Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental find...

Langerhans Cell Histiocytosis (LCH) is an uncommon neoplastic disorder characterized by accumulation of histiocytes in various tissues. The clinical manifestation is highly variable, ranging from an isolated skin rash or a single bony lesion, to fatal multi-organ failure. Due to its rarity and systemic involvement, the epidemiology of LCH is still not fully understood and most studies focus on ...

RATIONALE Lobular capillary hemangioma (LCH) of the tracheobronchial tree is a rare benign tumor, whose characteristics and treatments remain relatively unknown. PATIENT CONCERNS A 39-year-old man with hemoptysis caused by neoplasm in the bronchus intermedius was admitted to our hospital. DIAGNOSES The patient was diagnosed with LCH. INTERVENTIONS The lesions were removed with biopsy forc...

Hemorrhagic pustules with a "blueberry muffin" appearance accompanied by respiratory failure in a neonate present a challenging differential diagnosis that includes infections and neoplasms. We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. Infants with LCH pose a diagnostic challenge due to thei...

For $1$-dimensional Legendrian submanifolds of $1$-jet spaces, we extend the functorality contact homology DG-algebra (DGA) from embedded exact Lagrangian cobordisms, as in \cite{EHK}, to a class immersed cobordisms by considering their lifts conical cobordisms. To cobordism $\Sigma$ $\Lambda_-$ $\Lambda_+$, associate an DGA map, which is diagram $$\alg(\Lambda_+) \stackrel{f}{\rightarrow} \alg...

Prompted by evidence that Langerhans cell histiocytosis (LCH) is a nonmalignant disorder of immune regulation, we used cyclosporine (12 mg/kg/d orally) to treat three young children with advanced multisystem LCH. All three patients had partial responses to cyclosporine within 2 months of therapy, as evidenced by complete resolution of organ dysfunction and regression of the majority of lesions....