Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, 2012). In their follow‐up study in this issue of EMBO Molecular Medicine, white adipose tissue (WAT) and liver are identified as the physiologica...

The typical values that can be obtained by employing a business process support (BPS) system are optimization, compliance to rules and regulations, leanness, etc. These are obtained by introducing a kind of “conveyor belt” in business processes. While these values can be important for some processes at some phases of the enterprise development, they can be counter-productive for other processes...

Maintenance of body temperature in cold-exposed animals requires induction of thermogenesis and management of fuel. Here, we demonstrated that reducing ambient temperature attenuated diet-induced obesity (DIO), which was associated with increased iBAT thermogenesis and a plasma bile acid profile similar to that of germ-free mice. We observed a marked shift in the microbiome composition at the p...

Sterile alpha motif domain containing protein 4 (Samd4) is an RNA binding protein that mediates translational repression. We identified a Samd4 missense mutation, designated supermodel, that caused leanness and kyphosis associated with myopathy and adipocyte defects in C57BL/6J mice. The supermodel mutation protected homozygous mice from high fat diet-induced obesity, likely by promoting enhanc...

Given the centrality of body dissatisfaction in the manifestation of eating, exercise, and affective disturbances in men, measurement of this construct becomes essential. Across 2 studies with male undergraduates (Ns = 189 and 188), the psychometric properties, including incremental validity and factor structure, of the 25-item Body Parts Satisfaction Scale for Men (BPSS-M) were examined. Three...

That body weight is regulated has been evident to physiologists for many years. When access to food is restricted, animals increase their desire for food and indulge heartily when food reappears. To conserve energy during caloric restriction, appetite is regulated and the overall metabolic rate declines. Conversely, to resist obesity, forced overfeeding suppresses appetite and increases metabol...

Product development performance has become a critical-to-success aspect in this age of globalization and international competition. Platform based strategy could be used to enhance and support the efficiency and effectiveness of product development performance, as this paper suggests. This paper explores the impact of platform-based strategy on product development flexibility, product developme...

OBJECTIVE The objectives of the study were to examine the prevalence of anorexia nervosa (AN), bulimia nervosa (BN), anorexia athletica (AA), and eating disorders not otherwise specified (ED-NOS) in both male and female Norwegian elite athletes and a representative sample from the general Norwegian population. DESIGN A 2-step study including self-reported questionnaire and clinical interview....