an increase of LV work performed in a few patients; in the remainder the left ventricle performed less work. In four dogs, selective left coronary arteriography resulting in increased ventricular filling pressure, was accompanied by an increase of left ventricular end-diastolic (VED) and stroke volumes; the ejection fraction and heart rate remained unchanged. If the animal studies (increased VE...

The haemodynamic effects of dopamine and isosorbide dinitrate alone and in combination were studied in 8 patients with chronic congestive cardiac failure. In 7 patients dopamine, 6,tg/kg per min, increased mean cardiac index from 2-0 to 3 0 1/min per m2 (P < 0.0005); mean stroke volume index from 20 to 27 ml/m2 (P < 0.0025), and mean left ventricular stroke work index from 14 to 20 g M/M2 (P < ...

The influence of the pericardium on right and left ventricular filling was studied using two-dimensional and Doppler echocardiography in 14 open-chest dogs. Doppler echo parameters of filling included early (E) and late (A) velocities and their ratio (E/A) for the mitral and tricuspid valves. Right and left ventricular volumes were calculated from orthogonal two-dimensional echocardiographic im...

Exercise might reduce blood pressure in mild essential hypertensive individuals, but it could raise left ventricular mass, counteracting the beneficial effects induced by a decrease in blood pressure. Seventeen (group 1) of 25 mild hypertensive patients, nonresponders to a 3-month low sodium diet (2 g/day), were admitted into a physical training program consisting of three weekly sessions of ae...

One hundred and nineteen patients with a clinical diagnosis of important aortic stenosis were assessed clinically and by electrocardiography and M mode echocardiography to determine the degree of left ventricular hypertrophy. Predicted left ventricular pressure was calculated from two previously described formulas. Comparisons were made between the various methods for assessing left ventricular...

Since the dimensions of the ventricles are related to both myocardial tension and myocardial oxygen consumption (MVO2), the effects of nitroglycerin on the left ventricular volumes and left ventricular haemodynamics were studied in patients with ischaemic heart disease. The ventricular volumes were estimated using the constant infusion technique (indocyanine green) of Shaffer (1964). Sublingual...

OBJECTIVE To investigate left ventricular elastance (Emax) and effective arterial elastance (Ea) in postinfarction left ventricular aneurysm and evaluate their role in left ventricular function improvement after endoventricular circular patch plasty (EVCPP). Ventriculoarterial coupling has never been studied in these patients. PATIENTS 22 consecutive patients (49 to 73 years) with left ventri...

OBJECTIVE The purpose of this study was to quantify the magnitude of interaction between the right and left ventricles in conditions of heart failure. METHODS Human hearts were taken from transplant recipients diagnosed with diluted cardiomyopathy at the time of transplantation and were restored to beating condition with use of an isolated perfusion circuit. Left ventricular-right ventricular...