BACKGROUND Leishmania infantum recently has been identified as a possible agent of cutaneous leishmaniasis (CL). This species has been isolated from cutaneous lesions of patients from the Mediterranean Basin. However, little is known about the clinical, biological, or therapeutic features of this newly recognized CL. OBSERVATIONS Six patients aged 9 months to 85 years in southeastern France w...

A.1.) Leishmania major sphingolipids and ethanolamine lipids ......................................... 3 A.1.a.) Sphingolipids are essential for differentiation but not growth in Leishmania .................... 3 A.1.b.) Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. ....................................................................

Leishmaniasis represents a serious threat to the health as one of the most important neglected tropical diseases as designated by the World Health Organization. The disease is endemic in 82 countries, among them Tunisia is an indigenous area for cutaneous Leishmaniasis. In a previous work, two tritepenic acids namely oleanolic and maslinic acids have been isolated from olive leaf extract. In th...

Zoonotic visceral leishmaniasis is caused by Leishmania infantum (L. infantum),and its major reservoir hosts are domestic dogs, most of which are asymptomatic. This study aimed to detect L. infantum spp. in asymptomatic stray dogs by molecular and serological methods in Mashhad, Iran, during 2011-12. In this study, 94 asymptomatic stray dogs were randomly selected and their blood samples were c...

The importance of the genus Thrichomys in the retention of infection and transmission of Leishmania species is supported by previous studies that describe an ancient interaction between caviomorphs and trypanosomatids and report the natural infection of Thrichomys spp. Moreover, these rodents are widely dispersed in Brazil and recognized as important hosts of other tripanosomatids. Our main pur...

BACKGROUND Visceral leishmaniasis (kala-azar) is an endemic disease in some areas of Iran. A cross- sectional study was conducted for sero-epidemiological survey of visceral leishmaniasis (VL) in Baft district from Kerman Province, southeast of Iran. METHODS Blood samples were collected from children up to 12 years old and 10% of adult population from Baft villages with a multi-stage randomiz...

Leishmaniasis is a widespread neglected tropical disease caused by parasites of the Leishmania genus. These parasites express the enzyme 3'-nucleotidase/nuclease (3'NT/NU), which has been described to be involved in parasite nutrition and infection. Bacteria that express nucleases escape the toxic effects of neutrophil extracellular traps (NETs). Hence, we investigated the role of 3'NT/NU in Le...

Introduction: leishmaniasis is a disease caused by protozoa of the genus Leishmania and considered endemic in 98 countries. Treatment with pentavalent antimonials has high toxicity, which motivates search for effective less toxic drugs. α- β-lapachones have shown different biological activities, including antiprotozoa. In recent studies, isonicotinoylhydrazone phthalazinylhydrazone groups were ...

The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes Leishmania infantum promastigotes. U. showed against both parasites with IC50 values 7 µg/mL 31 µg/mL, respectively. Fractionation led to isolation euparin, jaceidin, santhemoidin C, eucannabinolide. sesquiterpene lactones eucan...