Levamisole, an anthelmintic veterinary product is known to be used as an additive to cocaine that enhances the psychotropic effects of this substance. This mixture leads to reactions such as agranulocytosis, skin vasculitis and modulation of the immune system. Only the proper recognition, treatment of this entity and discontinuation of this substance consumption, leads to the disappearance of l...

In a double blind study, the immunomodulator drug levamisole was administered along with chloropromazine to 18 schizophrenic patients, and efficiency of the combination was compared to that of chloropromazine along with placebo administered to 16 schizophrenic patients. The decrease in T suppressor cell count found in both groups at benchmark was found to be corrected in the patients receiving ...

A 45-year-old man presented with a 48-hour history of cognitive impairment. On clinical examination, the patient showed severe apathy, temporospatial disorientation, and mild right hemiparesis. Vital parameters were normal, no extraneurological signs identified. He had past medical history. reported cocaine consumption in 10 previous days. Cerebral magnetic resonance imaging (MRI; Fig) multiple...

Background Idiopathic nephrotic syndrome is a kidney involvement that causes edema and heavy proteinuria with severe complications if the treatment is started late. The present study aimed to assess the efficacy of Levamisole in the daily versus every other day treatment regimen to control recurrence in Childhood Idiopathic Nephrotic Synd...

The immunopotentiating drug, levamisole, was found to augment human lymphocyte responses to allogeneic cells and plant mitogens in vitro. The effect was critically dose dependent and, at high doses, suppression rather than augmentation of the immune response was observed. Our hypothesis that augmentation of immune responses by the drug is due to the selective impairment of immunoregulatory supp...

PURPOSE Levamisole is an antihelmintic and immunomodulator used as a dewormer and in combination with other forms of chemotherapy to treat colon cancer, melanoma, and head and neck cancer. It has also been used for treating dermatologic disorders such as verrucae. However, its benefits remain controversial and serious side effects such as central nervous system toxicity are unexpected. CASE R...

inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency Article abstract—Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnos...