BACKGROUND Cardiac disease is the most common cause of morbidity and mortality in the United Kingdom. Even minor changes in thyroid hormone concentration may impact adversely on the cardiovascular system. Subclinical hypothyroidism (SCH) after admission for an acute cardiac problem has been associated with an increase in cardiac mortality and overall death. We have designed protocols for a pros...

BACKGROUND Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. OBJECTIVES To identify interventions used in the management of hypothyroidism a...

background: suppressive therapy with levothyroxine for reducing the size of thyroid nodules has not been really accepted. the purpose of this study was to assess the effect of levothyroxine on the size of benign thyroid nodules. methods: forty patients with confirmed benign nodule were randomly divided into two groups. group i received 50?g/day levothyroxin for six months but group ii did not t...

BACKGROUND Subclinical thyroid disease during pregnancy may be associated with adverse outcomes, including a lower-than-normal IQ in offspring. It is unknown whether levothyroxine treatment of women who are identified as having subclinical hypothyroidism or hypothyroxinemia during pregnancy improves cognitive function in their children. METHODS We screened women with a singleton pregnancy bef...