We instrument a higher-order logic programming search procedure to generate and check small proof witnesses for the Twelf system, an implementation of the logical framework LF. In particular, we extend and generalize ideas from Necula and Rahul [16] in two main ways: 1) We consider the full fragment of LF including dependent types and higher-order terms and 2) We study the use of caching of sub...

BACKGROUND Hypotension due to vasodilatation after spinal anesthesia (SA) may be harmful. Heart rate variability, an indirect measure of autonomic control, may predict hypotension. METHODS One hundred patients were studied. Retrospectively, heart rate variability was analyzed in 30 patients, classified depending on the lowest systolic blood pressure (SBP) after SA. Seventy patients were studi...

BACKGROUND AND PURPOSE Based on their ability to chelate metals, hydroxamate molecules and siderophores have been successfully used as metalloenzyme inhibitors. As the anthrax toxin lethal factor (LF) is a zinc (Zn)-metallopeptidase, an investigation of the ability of some small non-siderophore hydroxamate compounds, 5 hydroxamate-containing siderophores, and 1 catecholate siderophore was under...

DNA vaccines provide an attractive technology platform against bioterrorism agents due to their safety record in humans and ease of construction, testing, and manufacture. We have designed monovalent and bivalent anthrax plasmid DNA (pDNA) vaccines encoding genetically detoxified protective antigen (PA) and lethal factor (LF) proteins and tested their immunogenicity and ability to protect rabbi...

Lactoferrin (LF), a multifunctional milk protein, is known to inhibit in vitro infection by viruses such as herpes simplex virus type 1 (HSV-1). We evaluated the influence of LF feeding on the HSV-1 cutaneous infection of mice. Bovine LF was administered to mice and, after 10 d, the mice were infected with HSV-1. LF administration did not affect the viral clearance in the skin, but inhibited th...

Lactoferrin (Lf) is an 80 kDa iron-binding glycoprotein with multifunctional properties and useful for clinical and commercial applications. Currently, Lf has some advantages including, immune system modulation, antibacterial activity and as antioxidant in infant and adult of human as well as animal health. In the present study, antibacterial activity of Lf has been scrutinized after isolation ...

India accounts for over one-third of the world's burden of lymphatic filariasis (LF). Although most coastal districts of Orissa state (eastern India) are LF-endemic, the western districts of Orissa are considered non-endemic. During a large-scale insecticide-treated bed net/microfinance trial, we tested one randomly selected adult (age 15-60 years) for LF from a random sample of microfinance-me...

Let f be a cusp form of the Hecke space M0(λ, k, ) and let Lf be the normalized L-function associated to f . Recently it has been proved that Lf belongs to an axiomatically defined class of functions S̄. We prove that when λ ≤ 2, Lf is always almost primitive, i.e., that if Lf is written as product of functions in S̄, then one factor, at least, has degree zeros and hence is a Dirichlet polynomial...

LF is a dependent type theory in which many other formal systems can be conveniently embedded. However, correct use of LF relies on nontrivial metatheoretic developments such as proofs of correctness of decision procedures for LF’s judgments. Although detailed informal proofs of these properties have been published, they have not been formally verified in a theorem prover. We have formalised th...