Previous results from this laboratory suggested that the same active conformation of the lutropin/choriogonadotropin receptor (LHR) is involved in the stimulation of G proteins and in triggering the internalization of the bound agonist. We have now analyzed two naturally occurring, constitutively active mutants of the human LHR. These mutations were introduced into the rat LHR (rLHR) and are de...

Wireless ad hoc network is expected to be integrated with wired networks and many applications will communicate over these networks transparently. Some applications need a reliable end-to-end transmission while wireless networks have less reliability than wired ones inherently. There are various ways to satisfy this demand. Many studies have been dedicated to improve the throughput of a connect...

INTRODUCTION To improve laser hair removal (LHR) for dark skin, the fluence rate reaching the hair follicle in LHR is important. This paper presents the results of a comparative study examining the function of wavelength on dark skin types using 755 nm alexandrite and 810 nm diode lasers. METHODS The structure of the skin was created using a realistic skin model by the Advanced Systems Analys...

Remote sensing of HDO and CH4 could provide valuable information on environmental climatological studies. In a recent contribution, we reported 3.53 μm distributed feedback (DFB) inter-band cascade laser (ICL)-based heterodyne radiometer. the present work, details measurements inversions at Dunhuang, Northwest China. The instrument line shape (ILS) radiometer (LHR) is discussed firstly, spectra...

G protein-coupled receptors (GPCRs) are ubiquitous mediators of signaling of hormones, neurotransmitters, and sensing. The old dogma is that a one ligand/one receptor complex constitutes the functional unit of GPCR signaling. However, there is mounting evidence that some GPCRs form dimers or oligomers during their biosynthesis, activation, inactivation, and/or internalization. This evidence has...

Familial male-limited precocious puberty (MPP) is described in a 10 year old patient with typical symptoms of the disease. Sequence analysis of genomic DNA clearly demonstrated a heterozygous T1 193C transition in exon 11 of the LH receptor (LHR) gene, which results in M398T substitution in the second transmembrane helix of the protein product of this gene. The same mutation was found in the pa...

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