Lichen planus (LP) is an inflammatory skin condition with characteristic clinical and histopathological findings. Classic LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist, including oral, nail, linear, annular, atrophic, hypertrophic, inverse, eruptive, bullous, ulcerative, lichen planus pigmentosus, li...

background and aims. oral lichen planus (olp) is an immunologic disorder. a large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases. materials and methods. the present cross-sect...

Introduction: Lichen planus is a human exclusive, chronic inflammatory disease affecting skin and mucosa, particularly oral mucosa affecting the stratified squamous epithelia. Epithelial alterations in oral lichen planus (OLP) may lead to superimposed Candida infection, especially the normal flora Candida albicans. Therefore, this study was designed to assess the prevalence of Candida infection...

The close chromosomal proximity of major histocompatibility complex and tumour necrosis factor genes may suggest the involvement of the latter in the pathogenesis of immunological diseases associated with HLA antigenes. The major histocompatibility complex antigens may play a certain role in the pathogenesis of lichen planus. Therefore we examined the -308 promoter polymorphism of tumour necros...

Sir, Chronic graft-versus-host disease (GVHD) occurs in approximately 60 – 80% of patients who survive for 100 days after allogeneic bone marrow transplantation (BMT) (1). The skin is affected in almost all cases of chronic GVHD, with two distinct phases: the early chronic phase, characterized by lichenoid lesions similar to lichen planus, and the late chronic phase, with sclerodermatous lesion...

Lichen planus Drug Metformin Dr. Reuven Bergman, Department of Dermatology, Rambam Medical Center, POB 9602, 31096 Haifa (Israel) Lichen planus is a relatively common skin disorder of unknown etiology. A wide variety of drugs have been implicated in its cause, although in many cases there is insufficient evidence to differentiate them from the idiopathic disorder [1]. Among the oral hypoglycemi...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : lichen planus is recognized as an inflammatory disease of the skin with different morphologic patterns. different treatment modalities, including topical and systemic corticosteroids, methotrexate, cyclosporine, azathioprine, topical calcineurin inhibitors, and psoralen  plus uva ( puva), have been suggested f...

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to thei...

Oral lichen planus (OLP) is a relatively common mucosal disease that can present isolated or associated with cutaneous lichen planus. Contrarily to its cutaneous counterpart, though, OLP tends to be chronic, relapsing, and difficult to treat. Severe morbidity is related to erosive forms, and more aggressive presentations have been described, such as the "gingivo-vulvar syndrome". This article r...