Differential expression of Toll-like receptor (TLR) by conventional dendritic cells (cDCs) and plasmacytoid DC (pDCs) has been suggested to influence the type of immune response induced by microbial pathogens. In this study we show that, in vivo, cDCs and pDCs are equally activated by TLR4, -7, and -9 ligands. Type I interferon (IFN) was important for pDC activation in vivo in response to all t...

The natural killer group 2 member D (NKG2D) receptor and its ligands are important mediators of immune responses to tumors. NKG2D ligands are overexpressed in several malignant tumor types; however, the prognostic value of these ligands is unclear. Here, we aimed to elucidate the role of NKG2D ligands in extrahepatic cholangiocarcinoma (EHCC). We therefore investigated the expression of the NKG...

new macrocyclic polyether-diester ligands (3-5) containing the 4h-pyran-4-one subcyclic unit have been prepared by treating various glycols with dimethyl chelidonate (10). in the reaction of compound 10 with ethylene glycol and diethylene glycol, two noncyclic diester and tetraester (6-9) were produced in each case. the new marcocyclic ligand 4 formed stable complexes with benzylammonium perchl...

Abstract Precisely changing the optical properties of gold nanoclusters (AuNCs) with different ligands offers a promising prospect for highly sensitive and selective drug sensing. In this study, AuNCs were synthesized d -tryptophan ( -Trp) its derivatives as ligands. Optical measurements showed that -Trp@AuNCs produced higher fluorescence intensity shorter emission wavelength than -Trp-derivati...

Near-IR semiconductor colloidal nanoplatelets (NPs) are a new and promising class of materials for the development photodetectors because they can effectively absorb visible infrared optical radiation. In this work, we study photoconductivity HgTe with ligands 1,2-ethanedithiol tetrabutylammonium iodide. It has been shown that choice is key factor in achieving high operational characteristics. ...