Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.

In this project I started studying about dendrimers, their chemistry and their physics. After studying the dendrimer and its mechanism in light harvesting, the focus turned into simulating it. Using Visual Basic’s graphical capabilities, I have designed some programs to simulate the growth of the dendrimers. This will allow the user to easily understand and visualize the characteristics that ma...

Synthetic polyammonium/polyamine receptors are known to enhance ATP dephosphorylation in solution. ATP interaction with a G-3 poly(ethylene imine) dendrimer shows an unprecedented behaviour, the dendrimer catalyst being able to enhance or inhibit dephosphorylation of the nucleotide depending on the solution pH.

We present a contrast variation small-angle neutron scattering (SANS) study of a series of neutral PAMAM dendrimers in aqueous solutions using three different generations (G4-6) at a concentration of about 10 mg/mL. Varying the solvent hydrogen-deuterium ratio, the scattering contributions from the water molecules and the constituent components of PAMAM dendrimer can be determined. Using an ana...

A dendrimer described as a macromolecule characterized by its highly branched 3D structure which provides a high degree of surface functionality and versatility. Dendrimers also referred to as the “Polymers of the 21 century.” Dendrimers components, namely (1) an initiator core (2) Interior layers (generations) composed of repeating units, radically attached to the interior core. (3) Exterior (...

Dendrimers have emerged as promising multifunctional nanomaterials for drug delivery due to their well-defined size and tailorability. We compare two schemes to obtain methylprednisolone (MP)-polyamidoamine dendrimer (PAMAM-G4-OH) conjugate. Glutaric acid (GA) was used as a spacer to facilitate the conjugation. In scheme A, PAMAM-G4-OH was first coupled to GA and then further conjugated with MP...

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

The cell surface interaction between bacterial lipopolysaccharide (LPS), Toll-like receptor 4 (TLR4) and MD-2 is central to bacterial sepsis syndromes and wound healing. We have shown that a generation (G) 3.5 polyamidoamine (PAMAM) dendrimer that was partially glycosylated with glucosamine inhibits TLR4-MD-2-LPS induced inflammation in a rabbit model of tissue scaring. However, it was a mixtur...

in this article we introduce the notion of textit{fractal $omega$-operad} emerging from  a natural $omega$-operad associated to any coglobular object in the category of higher operads in batanin's sense, which in fact is a coendomorphism $omega$-operads. we have in mind coglobular object of higher operads which algebras are kind of higher transformations. it follows that this natural $omega$-op...