نتایج جستجو برای: lipid based nanoparticles
تعداد نتایج: 3164302 فیلتر نتایج به سال:
The effect of aluminum oxide nanoparticles (Al2O3) on the stability and conductivity BLM (the bilayer lipid membrane) in solution was studied. It has been shown that Al2O3 increase an electric field, becomes more stable with increasing their concentration. experimental data are analyzed terms well-known theory stability, which is based concept spontaneous formation microscopic pores BLM, develo...
in this thesis, a new optically active poly(amide-imide) (pai) was synthesized by the indirect polycondensation reaction of the l-phenylalanine based diacid chloride and 4,4?-diaminodiphenylether in the presence of triethylamine in n-methyl-2-pyrrolidone. the formation of pai was confirmed by ftir, 1h nmr and elemental analysis. in next step, the surface of titanium dioxide (tio2) nanoparticles...
cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulatio...
A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agentshas been developed, based on oil-in-water nanoemulsions. Physicochemical characterizations of the nanoparticles evidence highly stable lipid nanoemulsions with amorphous core of temperatureand compositiontunable viscosity. Particles display low in vitro cytotoxicity (IC50 > 300 μg/mL of lipids), and hi...
The cell-penetrating peptide (CPP) is one of the most attractive tools for efficiently delivering biomolecules to a target organelle. Here, we describe the use of octaarginine (R8)-modified lipid nanoparticles for the efficient and targeted in vivo delivery of siRNA to the liver. In this study, SR-BI (a scavenger receptor class B, member 1) was targeted by this nanoparticle. Our results demonst...
TLR9 recognizes CpG motifs present in pathogenic DNA and triggers potent immune responses. It is generally accepted that TLR9 distinguishes pathogenic DNA based, in part, on methylation status, where TLR9 binds unmethylated but not methylated CpG. However, we showed that methylated CpG induces potent TLR9-mediated responses when delivered in lipid nanoparticles. In this article, we report that ...
We report that a histidine based cationic lipid forms multi-bilayer nanotubes and the addition of metal ions such as Cu(2+) and Au(3+) induces transformation into single-bilayer nanotubes owing to coordination of the metal ions on the nanotube surface. The morphological transition was detected with X-ray scattering and electron microscopy. IR showed that the metal coordination is presumably the...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scavenger-receptor-mediated uptake of oxidized lipoproteins (oxLDL) in macrophages. Current treatments lack the ability to directly inhibit oxLDL accumulation and foam cell conversion within diseased arteries. In this work, we harness nanotechnology to design and fabricate a new class of nanoparticles (...
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