Apolipoproteins are important constituents of lipoprotein particles and play a central role in the transport and metabolism of lipids (Goldstein et al., 1983). Different lipoproteins and apo have been identified. Recent epidemiological studies have shown the importance of the apolipoprotein B, and its direct correlation with the incidence of coronary heart disease (Sattar et al., 2004; Olofsson...

Mutations in the Escherichia coli lpp gene resulting in the alterations of the COOH-terminal region of the lipoprotein have been isolated by oligonucleotide-directed mutagenesis. As might be expected, substitution of Lys78 with Arg78 completely abolished the formation of murein-bound lipoprotein. Each of the following single amino acid substitutions did not significantly affect the formation of...

Observational epidemiological studies have associated plasma lipid concentrations with risk for coronary heart disease (CHD), but these studies cannot distinguish cause from mere correlation. Human genetic studies, when considered with the results of randomized controlled trials of medications, can potentially shed light on whether lipid biomarkers are causal for diseases. Genetic analyses and ...

This review examines the association between the apolipoprotein (apo) var epsilon gene polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and cardiovascular disease. The apo var epsilon gene is located at chromosome 19q13.2. Among the variants of this gene, alleles (*) epsilon2, (*) epsilon3, and (*) epsilon4 constitute the common polymorphism found in most popu...

These data describe the phenotypic variability in a large cohort of patients confirmed to have homozygous familial hypercholesterolemia. Herein, we describe the observed relationship of treated low-density lipoprotein cholesterol with age. We also overlay the low-density lipoprotein receptor gene (LDLR) functional status with these phenotypic data. A full description of these data is available ...

Low vitamin B12 concentration has been shown to be a risk factor for cardio-metabolic traits in numerous observational studies; however, the relationship remained inconsistent. It is possible that certain genotypes jointly contribute diseases and deficiency, these may modulated by dietary factors. The main objective of this article summarise findings from GeNuIne (Gene-Nutrient Interactions) Co...

objective: liver x receptors (lxrs) are ligand-activated transcription factors of the nuclear hormonal receptor superfamily which modulate the expression of genes involved in cholesterol homeostasis. hence, further unraveling of the molecular function of this gene may be helpful in preventing cardiovascular diseases. materials and methods: this experimental intervention study included twelve ad...

The 10-kb deletion ("French Canadian mutation") of the low-density lipoprotein (LDL) receptor gene is the most common mutation causing familial hypercholesterolemia among subjects of French Canadian descent. In affected subjects, it results in a null allele of the LDL receptor gene and provides a unique opportunity to examine single-allele regulation of this gene in humans. We sought to ascerta...

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