According to the WHO’s recently released worldwide cancer data for 2020, liver ranks sixth in morbidity and third mortality among all malignancies. Hepatocellular carcinoma (HCC), most common kind of cancer, accounts approximately 80% primary malignancies is one leading causes death globally. The intractable tumor microenvironment plays an important role development progression HCC three major ...

Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present study evaluated the effects of the combined use of alcohol with a conventional chemical-induced mouse liver cancer model. The treatment of alcohol/diethylnitrosami...

Metformin has garnered considerable interest as a chemo-preventive and chemo-therapeutic agent given the increased risk of liver cancer among diabetic patients. This work was performed to illustrate the association between metformin use and survival of diabetic liver cancer patients. We conducted a comprehensive literature search of PubMed, Web of Science, Embase, BIOSIS Previews, Cochrane Libr...

The purpose of this study was to investigate the expression of miR-375 and miR-221 in liver cancer, and examine the correlations with pathological parameters and prognosis. We collected tumors and tumor-adjacent normal tissue from 70 patients with liver cancer admitted to the Department of General Surgery of Zhejiang Hospital. The expression of miR-375 by RT-qPCR was significantly lower in live...

Metastasis is a poor prognostic factor for gastric cancer. Disparities between African-Americans and Caucasians in metastasis patterns require further investigation. Thus, this study aims to compare the of among different histological subtypes We obtained data 38,625 patients from Surveillance, Epidemiology, End Results Program (SEER) database 2010-2019. extracted with adenocarcinoma, signet ri...

Abstract Genetic heterogeneity of tumor is closely related to its clonal evolution, phenotypic diversity and treatment resistance, such has only been characterized at single-cell sub-chromosomal scale in liver cancer. Here we reconstructed the single-variant resolution evolution human cancer based on mutational profiles. The results indicated that key genetic events occurred early during tumori...

OBJECTIVE The aim of this study is to evaluate the liver metastasis risk among colorectal cancer patients with liver cirrhosis. METHODS This was a nationwide population-based cohort study of 2973 newly diagnosed colorectal cancer patients with liver cirrhosis and 11 892 age-sex matched controls enrolled in Taiwan between 2000 and 2010. The cumulative risk by Kaplan-Meier method, hazard ratio ...

Background Colorectal liver metastases (CRLM) can be encased in a fibrous capsule separating cancer from normal tissue, which correlates with increased patient survival. This study elucidates cellular and molecular mechanisms of formation the possible role epithelial mesenchymal transition (EMT).

AIM This paper investigates the correlation between liver cancer mortality and consumption of food-groups in Serbia. METHODS We conducted an ecological study. The study comprised the population of the Republic of Serbia (about 7.5 million inhabitants) during the period 1991-2010. This ecological study included the data on food consumption per capita which were obtained by the Household Budget...

OBJECTIVES To provide an up-to-date overview of long-term trends of liver cancer mortality and evaluate the effects attributable to age, period and cohort in Chinese population stratified by gender and urban/rural areas. METHODS Population and liver cancer mortality data were obtained based on the Disease Surveillance Points in China from 1991 to 2014. To examine the time trends of liver canc...