The stratum corneum serves as a critical barrier between the host and its external environment. Rich in ceramides, is one of largest sphingolipid reservoirs body. Our recent work using bioorthogonal labeling strategy traced sphingolipids from gut commensal Bacteroides thetaiotaomicron (BT) to liver mice fed with fat-free/high-sucrose diet demonstrated direct transfer labeled BT-sphingolipid liv...

Liver injury is a common pathological basis of various liver diseases, and long-term liver injury is often an important initiation factor leading to liver fibrosis and even liver cirrhosis and hepatocellular carcinoma (HCC). It has been reported that deproteinized extract of calf blood (DECB) can inhibit the replication of hepatitis B virus and confers a protective effect on the liver after tra...

Chronic ethanol consumption disrupts several metabolic pathways including β-oxidation and lipid biosynthesis, facilitating the development of alcoholic fatty liver disease. Many of these same metabolic pathways are directly regulated by cell autonomous circadian clocks, and recent studies suggest that disruption of daily rhythms in metabolism contributes to multiple common cardiometabolic disea...

BACKGROUND Liver cirrhosis is the most important risk factor for hepatocellular carcinoma (HCC) but the role of liver disease aetiology in cancer development remains under-explored. We investigated global gene expression profiles from HCC arising in different liver diseases to test whether HCC development is driven by expression of common or different genes, which could provide new diagnostic m...

UNLABELLED BACKGROUND The possibility of extracting RNA and measuring RNA expression from paraffin sections can allow extensive investigations on stored paraffin samples obtained from diseased livers and could help with studies of the natural history of liver fibrosis and inflammation, and in particular, correlate basic mechanisms to clinical outcomes. RESULTS To address this issue, a pilo...

This work presents an updated and more complete version of the transcriptome a long-distance migrant, Northern Wheatear (Oenanthe oenanthe). The improved was produced from independent mRNA sequencing adipose tissue, brain, intestines, liver, skin, muscle tissues sampled during autumnal migratory season. new has better coverage is representative species’ phenotype. We assembled 20,248 transcript...

The development of a polycystic liver is characteristic the monogenic disorders: autosomal dominant kidney disease (ADPKD), recessive (ARPKD), and (ADPLD). Respectively two one genes mainly cause ADPKD ARPKD. In contrast, ADPLD caused by at least six different which combined do not even explain in over half population. Genetic testing performed to confirm likelihood developing PKD if renal ther...